RegulonDB RegulonDB 10.10: Regulon Form
   
   


AscG,CRP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cyclic-AMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
AscG      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional repressor AscG, Sac
Gene name(s): ascG
Functional conformation(s): AscG
Coregulator(s): AscG, CRP, Fur, HypT, PdhR, PhoB, PrpR
Summary: TF Summary ...[more]

REGULATION EXERTED BY AscG,CRP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
AscG repressor CRP activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
AscG repressor ascFp ascF , ascB 2839426 2839440 4.5 catgattttgTGAAACCGGTTTCTTaattccgttt [GEA] [1]
CRP-cyclic-AMP activator ascFp ascF , ascB 2839347 2839368 -71.5 ggaaaaatatTCAGGTGACCGGTTTCACAAATataaaaaatg   [1]
AscG repressor ascFp ascF , ascB 2839350 2839364 -72.5 aaaatattcaGGTGACCGGTTTCACaaatataaaa [GEA] [2]
[1]
AscG repressor CRP dual    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cyclic-AMP activator ybiTp ybiT 855839 855861 -97.5 cagtgaaatcAGATGTGTACGAAATCACATTTTttgcctttgg [APIORCISFBSCS]
[GEA]
[3]
[4]
[5]
AscG repressor ybiTp ybiT 855832 855846 -108.5 cagctcacagTGAAATCAGATGTGTacgaaatcac   [1]
CRP-cyclic-AMP repressor ybiTp ybiT 855839 855861 -97.5 cagtgaaatcAGATGTGTACGAAATCACATTTTttgcctttgg [APIORCISFBSCS]
[GEA]
[3]
[4]
[5]

Evidence: [GEA] Gene expression analysis
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
Reference(s): [1] Ishida Y., et al., 2009
[2] Hall BG., et al., 1992
[3] Raghavan R., et al., 2011
[4] Tsai MJ., et al., 2018
[5] Zheng D., et al., 2004



Reference(s)    

 [1] Ishida Y., Kori A., Ishihama A., 2009, Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon., J Bacteriol 191(19):6136-44

 [2] Hall BG., Xu L., 1992, Nucleotide sequence, function, activation, and evolution of the cryptic asc operon of Escherichia coli K12., Mol Biol Evol 9(4):688-706

 [3] Raghavan R., Sage A., Ochman H., 2011, Genome-wide identification of transcription start sites yields a novel thermosensing RNA and new cyclic AMP receptor protein-regulated genes in Escherichia coli., J Bacteriol 193(11):2871-4

 [4] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951

 [5] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93


RegulonDB