RegulonDB RegulonDB 11.1: Regulon Form
   
   


CRP,Cra,PrpR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cyclic-AMP
Coregulator(s): AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Cra Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl
Gene name(s): cra
Functional conformation(s): Cra-beta;-D-fructose 1,6-bisphosphate , Cra , Cra-β-D-fructofuranose 1-phosphate
Coregulator(s): AcrR, ArcA, BasR, BetI, BolA, BtsR, CRP, CpxR, Cra, CsgD, CusR, DcuR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsAB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PrpR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator PrpR, YahP
Gene name(s): prpR
Functional conformation(s): PrpR-(2S,3S)-2-methylcitrate , PrpR
Coregulator(s): AscG, CRP, Cra, PhoB, PrpR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,Cra,PrpR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator Cra repressor PrpR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PrpR-(2S,3S)-2-methylcitrate activator prpBp prpB , prpC , prpD , prpE 348487 348510 -147.5 gtttagtcttGTTTCATAATTGTTGCAATGAAACgcggtgaaac [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
CRP-cyclic-AMP activator prpBp prpB , prpC , prpD , prpE 348529 348551 -106.5 acattgcctgAAACGTTAACTGAAACGCATATTtgcggattag [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
Cra repressor prpBp prpB , prpC , prpD , prpE 348536 348553 -101.5 ctgaaacgttAACTGAAACGCATATTTGcggattagtt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [2]
PrpR-(2S,3S)-2-methylcitrate activator prpBp prpB , prpC , prpD , prpE 348521 348544 -113.5 gcggtgaaacATTGCCTGAAACGTTAACTGAAACgcatatttgc    

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Lee SK., et al., 2005
[2] Shimada T., et al., 2011



Reference(s)    

 [1] Lee SK., Newman JD., Keasling JD., 2005, Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein., J Bacteriol 187(8):2793-800

 [2] Shimada T., Yamamoto K., Ishihama A., 2011, Novel members of the Cra regulon involved in carbon metabolism in Escherichia coli., J Bacteriol 193(3):649-59

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