RegulonDB

TRANSCRIPTION FACTOR:

Name:

CRP	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB

Gene name(s):

crp

Functional conformation(s):

CRP , CRP-cyclic-AMP

Coregulator(s):

AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

UxuR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional repressor UxuR

Gene name(s):

uxuR

Functional conformation(s):

UxuR , UxuR-D-fructuronate , UxuR-α-D-glucuronate-α-D-galacturonate

Coregulator(s):

CRP, ExuR, OxyR, UidR, UxuR

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

UidR	Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External sensing using transported metabolites

Synonym(s):

DNA-binding transcriptional repressor UidR, GusR

Gene name(s):

uidR

Functional conformation(s):

UidR

Coregulator(s):

CRP, UidR, UxuR

Summary:

TF Summary ...[more]

REGULATION EXERTED BY CRP,UidR,UxuR

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
CRP activator UidR repressor UxuR repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
CRP-cyclic-AMP	activator	uidAp	uidC , uidB , uidA	1696231	1696253	-89.5	gttttaaagaTTAATGCGATCTATATCACGCTGtgggtattgc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2]
UxuR	repressor	uidAp	uidC , uidB , uidA	1696116	1696133	28.5	gtgcaacacaGAATTGGTTAACTAATCAgattaaaggt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [3]
UidR	repressor	uidAp	uidC , uidB , uidA	1696298	1696313	-153.5	tcgttcccaaTACGCTCGAACGAACGttcggttgct	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [3]

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Blanco C., et al., 1985 [2] Tsai MJ., et al., 2018 [3] Blanco C., et al., 1986

Reference(s)
[1] Blanco C., Mata-Gilsinger M., Ritzenthaler P., 1985, The use of gene fusions to study the expression of uidR, a negative regulatory gene of Escherichia coli K-12., Gene 36(1-2):159-67
[2] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951
[3] Blanco C., Ritzenthaler P., Mata-Gilsinger M., 1986, Negative dominant mutations of the uidR gene in Escherichia coli: genetic proof for a cooperative regulation of uidA expression., Genetics 112(2):173-82