RegulonDB RegulonDB 11.1: Regulon Form
   
   


ArcA,CRP,RhaS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cyclic-AMP
Coregulator(s): AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA-phosphorylated , ArcA
Coregulator(s): AdiY, AppY, ArcA, BetI, BtsR, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RhaS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional activator RhaS
Gene name(s): rhaS
Functional conformation(s): RhaS-α-L-rhamnopyranose , RhaS , RhaS-L-rhamnose
Coregulator(s): ArcA, CRP, RhaR, RhaS
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,CRP,RhaS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor CRP activator RhaS activator RhaS unknown    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
RhaS-L-rhamnose activator rhaTp rhaT 4100632 4100648 -74.0 aatcacccacTTAATGCCGTGATTGCCagtaaatcga [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
RhaS-L-rhamnose activator rhaTp rhaT 4100599 4100615 -41.0 tcgacaacggCGGCAACAGGCGAAAGGttaatcgaca [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
CRP-cyclic-AMP activator rhaTp rhaT 4100649 4100671 -93.5 gaaaatgcccGAGATGTGAAGCAAATCACCCACttaatgccgt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [3]
[1]
[4]
ArcA-phosphorylated repressor rhaTp rhaT 4100715 4100729 -156.0 aaatgatattGAAAATGATTATCAAtgccgtactt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [5]
ArcA-phosphorylated repressor rhaTp rhaT 4100743 4100757 -184.0 gtaagcagttGGTTCATTATAGTTAattaaatgat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [5]
ArcA-phosphorylated repressor rhaTp rhaT 4100732 4100746 -173.0 gttcattataGTTAATTAAATGATAttgaaaatga [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [5]
RhaS unknown rhaTp rhaT 4101057 4101073 -499.0 cttttttcagACCTTTCCAGAACAGGCtgtggttagc   [2]

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Via P., et al., 1996
[2] Wickstrum JR., et al., 2007
[3] Tsai MJ., et al., 2018
[4] Zheng D., et al., 2004
[5] Liu X., et al., 2004



Reference(s)    

 [1] Via P., Badia J., Baldoma L., Obradors N., Aguilar J., 1996, Transcriptional regulation of the Escherichia coli rhaT gene., Microbiology 142 ( Pt 7):1833-40

 [2] Wickstrum JR., Skredenske JM., Kolin A., Jin DJ., Fang J., Egan SM., 2007, Transcription activation by the DNA-binding domain of the AraC family protein RhaS in the absence of its effector-binding domain., J Bacteriol 189(14):4984-93

 [3] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951

 [4] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [5] Liu X., De Wulf P., 2004, Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling., J Biol Chem 279(13):12588-97

RegulonDB