RegulonDB RegulonDB 11.1: Regulon Form
   
   


FNR,FlhDC,ModE,NarL,NarP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ModE Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): ChlD, DNA-binding transcriptional dual regulator ModE, ModE-MoO42-, ModR
Gene name(s): modE
Functional conformation(s): ModE , ModE-molybdate
Coregulator(s): ArcA, CRP, CytR, DeoR, FNR, FhlA, Fis, FlhDC, Fur, IHF, Lrp, ModE, NarL, NarP, NsrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[4Fe-4S]2+ reduced , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BtsR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NarL Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NarL, FrdR, NarR, nitrate/nitrite response regulator NarL
Gene name(s): narL
Functional conformation(s): NarL , NarL-phosphorylated
Coregulator(s): AppY, ArcA, CRP, Cra, DcuR, DpiA, EvgA, FNR, FhlA, Fis, FlhDC, Fur, H-NS, IHF, IscR, Lrp, ModE, NagC, NarL, NarP, NikR, NorR, NsrR, OxyR, PhoP, RcsB, RstA, SoxS, TorR, UvrY, YdeO
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NarP Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NarP, nitrate/nitrite response regulator NarP
Gene name(s): narP
Functional conformation(s): NarP , NarP-phosphorylated
Coregulator(s): AppY, ArcA, CRP, Cra, EvgA, FNR, FhlA, Fis, FlhDC, H-NS, IHF, IscR, ModE, NagC, NarL, NarP, NorR, NsrR, OxyR, PhoP, RcsB, UvrY, YdeO
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FlhDC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): FlhDC DNA-binding transcriptional dual regulator
Gene name(s): flhC, flhD
Functional conformation(s): FlhDC
Coregulator(s): ArcA, BtsR, CRP, CsgD, DpiA, FNR, FhlA, Fis, FlhDC, GalR, GalS, GlpR, H-NS, IHF, MatA, ModE, NarL, NarP, NsrR, PdeL, SutR
Summary: TF Summary ...[more]

REGULATION EXERTED BY FNR,FlhDC,ModE,NarL,NarP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
FNR activator FlhDC activator ModE activator NarL repressor NarP activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NarP-phosphorylated activator napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF 2303606 2303621 -40.0 ggttttacccCGATCGGGGTATGCATctttgacaca [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
NarP-phosphorylated activator napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF 2303615 2303630 -49.0 cctgctacagGTTTTACCCCGATCGGggtatgcatc [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
ModE-molybdate activator napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF 2303696 2303719 -133.5 gtgaatcaatCGCTATATAAATATATTTATAACCatttgaaatg [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [3]
[2]
FNR activator napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF 2303632 2303645 -64.5 cgccactcttTTGATCCTGCTACAggttttaccc [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
NarL-phosphorylated repressor napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF 2303620 2303626 -49.0 ctacaggtttTACCCCGatcggggtat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [4]
[1]
[2]
NarL-phosphorylated repressor napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF 2303611 2303617 -40.0 ttaccccgatCGGGGTAtgcatctttg [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [4]
[1]
[2]
FlhDC activator napFp1 ccmH , ccmG , ccmF , ccmE , ccmD , ccmC , ccmB , ccmA , napC , napB , napH , napG , napA , napD , napF

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Darwin AJ., et al., 1998
[2] Stewart V., et al., 2003
[3] McNicholas PM., et al., 2002
[4] Darwin AJ., et al., 1995



Reference(s)    

 [1] Darwin AJ., Ziegelhoffer EC., Kiley PJ., Stewart V., 1998, Fnr, NarP, and NarL regulation of Escherichia coli K-12 napF (periplasmic nitrate reductase) operon transcription in vitro., J Bacteriol 180(16):4192-8

 [2] Stewart V., Bledsoe PJ., Williams SB., 2003, Dual overlapping promoters control napF (periplasmic nitrate reductase) operon expression in Escherichia coli K-12., J Bacteriol 185(19):5862-70

 [3] McNicholas PM., Gunsalus RP., 2002, The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availability., J Bacteriol 184(12):3253-9

 [4] Darwin AJ., Stewart V., 1995, Nitrate and nitrite regulation of the Fnr-dependent aeg-46.5 promoter of Escherichia coli K-12 is mediated by competition between homologous response regulators (NarL and NarP) for a common DNA-binding site., J Mol Biol 251(1):15-29

 [5] Pruss BM., Liu X., Hendrickson W., Matsumura P., 2001, FlhD/FlhC-regulated promoters analyzed by gene array and lacZ gene fusions., FEMS Microbiol Lett 197(1):91-7

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