RegulonDB evolutionary first Genes of Regulon

Summary of evolutionary conservation promoters regulated by PurR

The evolutionary conservation of promoters is limited to Gammaproteobacteria and to sigma70 promoters. In general an promoter is conserved if, i) the position of the promoter from the gene start is conserved, or ii) the promoter sequence recognized by the sigma70 factor is conserved (p < 0.0001). To avoid redundancy, the orthologous regions were purged using the program Purge-Sequence from RSAtools. Orthologs consisted of BLAST reciprocal best hits using soft masking and Smith-Waterman alignments.

First gene Promoter name Evolutionary conservation ratio (nd) Footprint conservation
carA carAp1 0.29
carAp2 0.28
codB codBp 0.33
cvpA cvpAp1 0.12
cvpAp2 (nd)
gcvT gcvTp 0.03
glnB glnBp1 0.05
glnBp2 0.01
glnBp3 (nd)
glnB glnBp1 0.05
glnBp2 0.01
glnBp3 (nd)
glyA glyAp 0.08
guaB guaBp 0.08
hflD hflDp 0.07
prs lolBp (nd)
prsp 0.42
purA purAp 0.13
purC purCp 0.08
purE purEp 0.16
purH purHp 0.01
purL purLp 0.17
purM purMp 0.05
purR purRp 0.19
purT purTp (nd)
pyrC pyrCp 0.05
pyrD pyrDp 0.13
speA speAp 0.18