RegulonDB Summary of evolutionary conservation

Summary of evolutionary conservation of CpxR gene regulated (first gene of a TU) interactions

Evolutionary conservation in RegulonDB is limited to gammaproteobacteria. Conservation of a regulatory interaction, i.e. a TF regulating a target gene, is inferred from the overrepresentation of TFBSs in upstream regions of the orthologous target genes. We searched for TFBS conservation only in those genomes with an ortholog for the TF and for the regulated gene. Orthologs were selected based on a bidirectional best-hit procedure using RSAT tools package. Overrepresentation is calculated based on the binomial distribution; the binomial significance is shown in following table as significance of conservation.

First Gene Significance of conservation (nd) Footprint conservation
acrD nd
aroG 9.98
bacA 0 (Below threshold)
bamE 4.45 (Below threshold)
cpxP 35.22
cpxR 25.24
csgB 0 (Below threshold)
csgD 0 (Below threshold)
degP 0 (Below threshold)
dsbC nd
efeU_1 nd
ftnB 6.41
hlpA nd
mdtA 0 (Below threshold)
motA 5.09
ompC 0 (Below threshold)
ompF 1.74 (Below threshold)
ppiA 27.40
ppiD 0 (Below threshold)
psd 1.86 (Below threshold)
rdoA 0 (Below threshold)
rpoE 0 (Below threshold)
rpoH 0 (Below threshold)
spy 23.43
tomB 0 (Below threshold)
tsr 0 (Below threshold)
ung 5.50
yccA 114.40
ycfS 9.22
ydeH 1.99 (Below threshold)
yebE 9.96
yidQ 0 (Below threshold)
yqjA 6.74