RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the GadE regulatory interaction in purA orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for purA was scanned with the annotated matrix for GadE. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitespurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_GadE_sites.tab
Ortholog predicted binding sites graphpurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_GadE_sites.jpg
genespurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencepurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologspurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencespurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencespurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigpurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_GadE_occ_sig.tab
Occ sig graphpurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_GadE_occ_sig.jpg
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Occ freq graphpurA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_GadE_occ_freq.jpg
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