RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the IscR regulatory interaction in hyaA orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for hyaA was scanned with the annotated matrix for IscR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding siteshyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_sites.tab
Ortholog predicted binding sites graphhyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_sites.jpg
geneshyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencehyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologshyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequenceshyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequenceshyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sighyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_occ_sig.tab
Occ sig graphhyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_occ_sig.jpg
(Click on image below)
Occ freq graphhyaA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_occ_freq.jpg
(Click on image below)
RegulonDB