RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the IscR regulatory interaction in sufA orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for sufA was scanned with the annotated matrix for IscR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitessufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_sites.tab
Ortholog predicted binding sites graphsufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_sites.jpg
genessufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencesufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologssufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencessufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencessufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigsufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_occ_sig.tab
Occ sig graphsufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_occ_sig.jpg
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Occ freq graphsufA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_IscR_occ_freq.jpg
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