RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MalT regulatory interaction in malK orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for malK was scanned with the annotated matrix for MalT. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_sites.tab
Ortholog predicted binding sites graphmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_sites.jpg
genesmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencemalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_occ_sig.tab
Occ sig graphmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_occ_sig.jpg
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Occ freq graphmalK_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_occ_freq.jpg
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