RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MalT regulatory interaction in malS orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for malS was scanned with the annotated matrix for MalT. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_sites.tab
Ortholog predicted binding sites graphmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_sites.jpg
genesmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencemalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_occ_sig.tab
Occ sig graphmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_occ_sig.jpg
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Occ freq graphmalS_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MalT_occ_freq.jpg
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