RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MetJ regulatory interaction in folE orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for folE was scanned with the annotated matrix for MetJ. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_sites.tab
Ortholog predicted binding sites graphfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_sites.jpg
genesfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencefolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_sig.tab
Occ sig graphfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_sig.jpg
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Occ freq graphfolE_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_freq.jpg
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