RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MetJ regulatory interaction in metA orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for metA was scanned with the annotated matrix for MetJ. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_sites.tab
Ortholog predicted binding sites graphmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_sites.jpg
genesmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencemetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_sig.tab
Occ sig graphmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_sig.jpg
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Occ freq graphmetA_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_freq.jpg
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