RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MetJ regulatory interaction in metN orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for metN was scanned with the annotated matrix for MetJ. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_sites.tab
Ortholog predicted binding sites graphmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_sites.jpg
genesmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencemetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_sig.tab
Occ sig graphmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_sig.jpg
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Occ freq graphmetN_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetJ_occ_freq.jpg
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