RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MetR regulatory interaction in metR orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for metR was scanned with the annotated matrix for MetR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetR_sites.tab
Ortholog predicted binding sites graphmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetR_sites.jpg
genesmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencemetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetR_occ_sig.tab
Occ sig graphmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetR_occ_sig.jpg
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Occ freq graphmetR_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MetR_occ_freq.jpg
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