RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MlrA regulatory interaction in cadC orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for cadC was scanned with the annotated matrix for MlrA. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitescadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MlrA_sites.tab
Ortholog predicted binding sites graphcadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MlrA_sites.jpg
genescadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencecadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologscadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencescadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencescadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigcadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MlrA_occ_sig.tab
Occ sig graphcadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MlrA_occ_sig.jpg
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Occ freq graphcadC_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MlrA_occ_freq.jpg
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