RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the MntR regulatory interaction in mntH orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for mntH was scanned with the annotated matrix for MntR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MntR_sites.tab
Ortholog predicted binding sites graphmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MntR_sites.jpg
genesmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencemntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MntR_occ_sig.tab
Occ sig graphmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MntR_occ_sig.jpg
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Occ freq graphmntH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_MntR_occ_freq.jpg
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