RegulonDB Gene Evolutionary Conservation
Evolutionary conservation of the TrpR regulatory interaction in aroH orthologous genes

In general an interaction is conserved if there is a significant overrepresentation of TFBSs in the set of orthologous promoters of the target gene. The set of orthologous promoter for aroH was scanned with the annotated matrix for TrpR. In order to avoid bias due to an excessive representation of close genomes (i.e. several E. coli genomes) we masked the regulatory sequences that were too similar. Overrepresentation is calculated based on the binomial distribution, comparing the observed scores vs. the expected ones for the masked sequence set.


Ortholog predicted binding sitesaroH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_TrpR_sites.tab
Ortholog predicted binding sites grapharoH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_TrpR_sites.jpg
genesaroH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_genes.tab
Query sequencearoH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_query_seq.fasta
OrthologsaroH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_bbh.tab
ortho sequencesaroH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq.fasta
Purged sequencesaroH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_ortho_seq_purged.fasta
Occ sigaroH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_TrpR_occ_sig.tab
Occ sig grapharoH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_TrpR_occ_sig.jpg
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Occ freq grapharoH_Escherichia_coli_K_12_substr__MG1655_uid57779_Gammaproteobacteria_TrpR_occ_freq.jpg
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