RegulonDB RegulonDB 11.1: Gene Form
   

aroG gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aroG gpmA ybgS CpxR TyrR TSS_926 TSS_926 TSS_925 (cluster) TSS_925 (cluster) TSS_924 (cluster) TSS_924 (cluster) TSS_923 TSS_923 TSS_922 TSS_922 TSS_921 (cluster) TSS_921 (cluster) TSS_920 (cluster) TSS_920 (cluster) TSS_919 TSS_919 TSS_918 (cluster) TSS_918 (cluster) TSS_917 (cluster) TSS_917 (cluster) aroGp aroGp ybgSp8 ybgSp8 ybgSp7 ybgSp7 TSS_915 TSS_915 ybgSp2 ybgSp2 TSS_914 TSS_914 ybgSp5 ybgSp5 ybgSp1 ybgSp1

Gene      
Name: aroG    Texpresso search in the literature
Synonym(s): ECK0743, EG10079, b0754
Genome position(nucleotides): 785633 --> 786685
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.14
External database links:  
ASAP:
 ABE-0002560
CGSC:
 1002
ECHOBASE:
 EB0077
ECOLIHUB:
 aroG
OU-MICROARRAY:
 b0754
STRING:
 511145.b0754
COLOMBOS: aroG


Product      
Name: 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive
Synonym(s): 2-dehydro-3-deoxyphosphoheptonate aldolase, AroG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 38.009
Isoelectric point: 6.576
Motif(s):
 
Type Positions Sequence Comment
38 -> 338 HARKAIHKILKGNDDRLLVVIGPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQINDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASGLSCPVGFKNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKEPNYSAKHVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESHLVEGNQSLESGEPLAYGKSITDACIGWEDTDALL

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.13 - phenylalanine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity
GO:0042802 - identical protein binding
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009058 - biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
GO:0009423 - chorismate biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] Ray JM., et al., 1988
External database links:  
ALPHAFOLD:
 P0AB91
DIP:
 DIP-35898N
ECOCYC:
 AROG-MONOMER
ECOLIWIKI:
 b0754
INTERPRO:
 IPR013785
INTERPRO:
 IPR006218
INTERPRO:
 IPR006219
MODBASE:
 P0AB91
PANTHER:
 PTHR21225
PDB:
 5CKS
PDB:
 1QR7
PDB:
 1N8F
PDB:
 1GG1
PDB:
 1KFL
PFAM:
 PF00793
PRIDE:
 P0AB91
PRODB:
 PRO_000022148
REFSEQ:
 NP_415275
SMR:
 P0AB91
UNIPROT:
 P0AB91


Operon      
Name: aroG         
Operon arrangement:
Transcription unit        Promoter
aroG


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR
Repressed by: TyrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ybgSp1 785339 reverse nd [COMP-AINF] [2]
  promoter ybgSp5 785373 reverse nd [COMP-AINF] [2]
  promoter TSS_914 785390 reverse nd [RS-EPT-CBR] [3]
  promoter ybgSp2 785459 reverse nd [COMP-AINF] [2]
  promoter TSS_915 785462 reverse nd [RS-EPT-CBR] [3]
  promoter ybgSp7 785465 reverse nd [COMP-AINF] [2]
  promoter ybgSp8 785496 reverse nd [COMP-AINF] [2]
  promoter TSS_917 (cluster) 785597 forward nd [RS-EPT-CBR] [3]
  promoter TSS_918 (cluster) 785602 forward nd [RS-EPT-CBR] [3]
  promoter TSS_919 785605 forward nd [RS-EPT-CBR] [3]
  promoter TSS_920 (cluster) 785607 forward nd [RS-EPT-CBR] [3]
  promoter TSS_921 (cluster) 785612 forward nd [RS-EPT-CBR] [3]
  promoter TSS_922 785622 forward nd [RS-EPT-CBR] [3]
  promoter TSS_923 785768 forward nd [RS-EPT-CBR] [3]
  promoter TSS_924 (cluster) 785886 forward nd [RS-EPT-CBR] [3]
  promoter TSS_925 (cluster) 785890 forward nd [RS-EPT-CBR] [3]
  promoter TSS_926 785897 forward nd [RS-EPT-CBR] [3]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Ray JM., Yanofsky C., Bauerle R., 1988, Mutational analysis of the catalytic and feedback sites of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli., J Bacteriol 170(12):5500-6

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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