RegulonDB RegulonDB 10.10: Gene Form
   

cdsA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

rseP cdsA uppS TSS_344 TSS_344 bamAp bamAp TSS_343 TSS_343 TSS_342 TSS_342 TSS_341 (cluster) TSS_341 (cluster) bamAp2 bamAp2 TSS_339 TSS_339 rsePp rsePp cdsAp2 cdsAp2 cdsAp3 cdsAp3 TSS_337 TSS_337 TSS_336 TSS_336 TSS_335 (cluster) TSS_335 (cluster) TSS_334 TSS_334

Gene      
Name: cdsA    Texpresso search in the literature
Synonym(s): ECK0174, EG10139, b0175, cds
Genome position(nucleotides): 195677 --> 196534 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.82
Reference(s): [1] Icho T., et al., 1985
External database links:  
ASAP:
 ABE-0000600
CGSC:
 930
ECHOBASE:
 EB0137
ECOLIHUB:
 cdsA
OU-MICROARRAY:
 b0175
STRING:
 511145.b0175
COLOMBOS: cdsA


Product      
Name: CDP-diglyceride synthetase
Synonym(s): Cds, CdsA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 31.454
Isoelectric point: 9.385
Motif(s):
 
Type Positions Sequence
31 -> 51 VTLVVCMLAAWEWGQLSGFTT
56 -> 76 VWLAVLCGLLLALMLFLLPEY
121 -> 141 LIFGVLTIVPFFWGMLALRAW
4 -> 279 YRLISAFVLIPVVIAALFLLPPVGFAIVTLVVCMLAAWEWGQLSGFTTRSQRVWLAVLCGLLLALMLFLLPEYHRNIHQPLVEISLWASLGWWIVALLLVLFYPGSAAIWRNSKTLRLIFGVLTIVPFFWGMLALRAWHYDENHYSGAIWLLYVMILVWGADSGAYMFGKLFGKHKLAPKVSPGKTWQGFIGGLATAAVISWGYGMWANLDVAPVTLLICSIVAALASVLGDLTESMFKREAGIKDSGHLIPGHGGILDRIDSLTAAVPVFACLLL
264 -> 284 IDSLTAAVPVFACLLLLVFRT

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.4 - fatty acids and phosphatidic acid
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.1 - phospholipid
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016779 - nucleotidyltransferase activity
GO:0016740 - transferase activity
GO:0016772 - transferase activity, transferring phosphorus-containing groups
GO:0004605 - phosphatidate cytidylyltransferase activity
biological_process GO:0006629 - lipid metabolic process
GO:0008654 - phospholipid biosynthetic process
GO:0016024 - CDP-diacylglycerol biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 CDPDIGLYSYN-MONOMER
ECOLIWIKI:
 b0175
INTERPRO:
 IPR000374
PFAM:
 PF01148
PRIDE:
 P0ABG1
PRODB:
 PRO_000022266
PROSITE:
 PS01315
REFSEQ:
 NP_414717
SMR:
 P0ABG1
UNIPROT:
 P0ABG1


Operon      
Name: dxr-ispZU-cdsA         
Operon arrangement:
Transcription unit        Promoter
uppS-cdsA
uppS-cdsA
cdsA
dxr-uppS-cdsA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_334 195472 forward nd [RS-EPT-CBR] [2]
  promoter TSS_335 (cluster) 195478 forward nd [RS-EPT-CBR] [2]
  promoter TSS_336 195482 forward nd [RS-EPT-CBR] [2]
  promoter TSS_337 195485 forward nd [RS-EPT-CBR] [2]
  promoter cdsAp3 195555 forward nd [ICWHO], [RS-EPT-CBR] [2], [3]
  promoter cdsAp2 195561 forward nd [ICWHO] [3]
  promoter TSS_339 196978 forward nd [RS-EPT-CBR] [2]
  promoter TSS_341 (cluster) 197487 forward nd [RS-EPT-CBR] [2]
  promoter TSS_342 197586 forward nd [RS-EPT-CBR] [2]
  promoter TSS_343 197588 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_344 197883 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Icho T., Sparrow CP., Raetz CR., 1985, Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli., J Biol Chem 260(22):12078-83

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

RegulonDB