RegulonDB RegulonDB 10.10: Gene Form
   

cstA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cstA entH ybdD CRP ybdDp2 ybdDp2 TSS_727 TSS_727 cstAp3 cstAp3 TSS_726 TSS_726 cstAp2 cstAp2 TSS_725 TSS_725 TSS_724 TSS_724 cstAp1 cstAp1

Gene      
Name: cstA    Texpresso search in the literature
Synonym(s): ECK0591, EG10167, b0598, ybdC
Genome position(nucleotides): 629894 --> 631999 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 57.22
External database links:  
ASAP:
 ABE-0002061
CGSC:
 31179
ECHOBASE:
 EB0165
ECOLIHUB:
 cstA
OU-MICROARRAY:
 b0598
STRING:
 511145.b0598
COLOMBOS: cstA


Shine dalgarno      
Sequence: gacacgcacaCGGATAacaactATG


Product      
Name: pyruvate transporter CstA
Synonym(s): CstA, YbdC, carbon starvation protein A, cst-2
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 75.105
Isoelectric point: 7.995
Motif(s):
 
Type Positions Sequence
34 -> 54 ALWIVVASVCIYLIAYRFYGL
325 -> 345 LFPFLFITIACGAVSGFHALI
256 -> 276 LTWMLVGYGFVAAVLPVWLLL
551 -> 571 FGIANQMLAGMALMLCAVVLF
578 -> 598 YAWVALVPTAWLLICTLTAGW

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005477 - pyruvate secondary active transmembrane transporter activity
biological_process GO:0006849 - plasma membrane pyruvate transport
GO:0009267 - cellular response to starvation
GO:0015031 - protein transport
GO:0031669 - cellular response to nutrient levels
GO:0015833 - peptide transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 EG10167-MONOMER
ECOLIWIKI:
 b0598
INTERPRO:
 IPR025299
INTERPRO:
 IPR003706
PFAM:
 PF02554
PFAM:
 PF13722
PRIDE:
 P15078
PRODB:
 PRO_000022346
REFSEQ:
 NP_415130
SMR:
 P15078
UNIPROT:
 P15078


Operon      
Name: cstA         
Operon arrangement:
Transcription unit        Promoter
cstA
cstA
cstA


Transcriptional Regulation      
Display Regulation             
Activated by: CRP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_724 629856 forward nd [RS-EPT-CBR] [1]
  promoter TSS_725 629858 forward nd [RS-EPT-CBR] [1]
  promoter TSS_726 629865 forward nd [RS-EPT-CBR] [1]
  promoter TSS_727 629905 forward nd [RS-EPT-CBR] [1]
  promoter ybdDp2 631991 forward nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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