RegulonDB RegulonDB 11.1: Gene Form
   

fepD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

entS fepD fepG fepC fepE Fur Fur Fur Fur entSp1 entSp1 entSp2 entSp2 fepDp1 fepDp1 fepDp2 fepDp2

Gene      
Name: fepD    Texpresso search in the literature
Synonym(s): ECK0583, EG10296, b0590
Genome position(nucleotides): 621185 <-- 622189
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 61.0
External database links:  
ASAP:
 ABE-0002031
CGSC:
 18382
ECHOBASE:
 EB0292
ECOLIHUB:
 fepD
OU-MICROARRAY:
 b0590
STRING:
 511145.b0590
COLOMBOS: fepD


Product      
Name: ferric enterobactin ABC transporter membrane subunit FebD
Synonym(s): FepD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 33.871
Isoelectric point: 10.643
Motif(s):
 
Type Positions Sequence Comment
10 -> 30 AIAVPGLLLLLIIATALSLLI UniProt: Helical.
19 -> 328 LLIIATALSLLIGAKSLPASVVLEAFSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAIVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRVIVPGELRVSVVSAFIGAPVLIFLVRR
64 -> 84 TLAGLLAGGALGLAGALMQTL UniProt: Helical.
93 -> 113 GLLGVNAGASFAIVLGAALFG UniProt: Helical.
121 -> 141 LAMAFAGALVASLIVAFTGSQ UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.7 - Fe aquisition
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015620 - ferric-enterobactin transmembrane transporter activity
biological_process GO:0006811 - ion transport
GO:0055072 - iron ion homeostasis
GO:0055085 - transmembrane transport
GO:0033212 - iron import into cell
GO:0033214 - siderophore-dependent iron import into cell
GO:0015685 - ferric-enterobactin import into cell
Note(s): Note(s): ...[more].
Reference(s): [1] Chenault SS., et al., 1992
External database links:  
ALPHAFOLD:
 P23876
ECOCYC:
 FEPD-MONOMER
ECOLIWIKI:
 b0590
INTERPRO:
 IPR000522
INTERPRO:
 IPR037294
MODBASE:
 P23876
PANTHER:
 PTHR30472
PFAM:
 PF01032
PRIDE:
 P23876
PRODB:
 PRO_000022603
REFSEQ:
 NP_415122
SMR:
 P23876
UNIPROT:
 P23876


Operon      
Name: fepDGC         
Operon arrangement:
Transcription unit        Promoter
fepDGC
fepDGC


Transcriptional Regulation      
Display Regulation             
Repressed by: Fur


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Chenault SS., Earhart CF., 1992, Identification of hydrophobic proteins FepD and FepG of the Escherichia coli ferrienterobactin permease., J Gen Microbiol 138(10):2167-71

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