RegulonDB

Gene
Name:	fimH
Synonym(s):	ECK4311, EG10315, b4320, pilE
Genome position(nucleotides):	4548808 --> 4549710
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.17
External database links:

ASAP:	ABE-0014157
CGSC:	18337
ECHOBASE:	EB0311
ECOLIHUB:	fimH
OU-MICROARRAY:	b4320
STRING:	511145.b4320
COLOMBOS:	fimH

Product

Name:

type 1 fimbriae D-mannose specific adhesin

Synonym(s):

FimH, PilE, type 1 fimbrin minor protein

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

pilus,extracellular space

Molecular weight:

31.473

Isoelectric point:

7.878

Motif(s):

Type	Positions	Sequence	Comment
	1 -> 21	MKRVITLFAVLLMGWSVNAWS
	22 -> 300	FACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	UniProt: Type 1 fimbrin D-mannose specific adhesin.
	24 -> 168	CKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWN
	79 -> 79	L	UniProt: In Ref. 2; no nucleotide entry..
	175 -> 300	VVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.11 - glycoprotein
		6 - cell structure --> 6.5 - pilus
Gene Ontology Terms (GO)
	cellular_component	GO:0009419 - pilus tip GO:0009289 - pilus GO:0005576 - extracellular region GO:0033644 - host cell membrane
	molecular_function	GO:0005515 - protein binding GO:0005537 - mannose binding
	biological_process	GO:0007638 - mechanosensory behavior GO:0007155 - cell adhesion GO:0043709 - cell adhesion involved in single-species biofilm formation GO:0031589 - cell-substrate adhesion

Note(s):

Note(s): ...[more].

Evidence:

[EXP-IDA-PART-PURIFIED-PROTEIN-NH] Assay of protein partially-purified from its native host
[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Kallas P., et al., 2020
[2] Krogfelt KA., et al., 1990
[3] Sokurenko EV., et al., 1994

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Operon

Name:

fimAICDFGH

Operon arrangement:

Transcription unit	Promoter
fimAICDFGH	fimAp

Transcriptional Regulation
	Display Regulation
Activated by:	H-NS, IHF, Lrp, QseB

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Kallas P., Haugen HJ., Gadegaard N., Stormonth-Darling J., Hulander M., Andersson M., Valen H., 2020, Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae., Nanomaterials (Basel) 10(11)
[2] Krogfelt KA., Bergmans H., Klemm P., 1990, Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae., Infect Immun 58(6):1995-8
[3] Sokurenko EV., Courtney HS., Ohman DE., Klemm P., Hasty DL., 1994, FimH family of type 1 fimbrial adhesins: functional heterogeneity due to minor sequence variations among fimH genes., J Bacteriol 176(3):748-55

RegulonDB