RegulonDB RegulonDB 10.10: Gene Form
   

ftsW gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

murC murD ftsW mraY murG ddlB murF TSS_173 (cluster) TSS_173 (cluster) TSS_172 TSS_172 TSS_171 TSS_171 TSS_170 TSS_170 TSS_169 TSS_169 TSS_168 TSS_168 TSS_167 TSS_167 TSS_166 TSS_166 TSS_165 TSS_165 TSS_164 TSS_164 TSS_163 (cluster) TSS_163 (cluster) TSS_162 TSS_162

Gene      
Name: ftsW    Texpresso search in the literature
Synonym(s): ECK0090, EG10344, b0089
Genome position(nucleotides): 98403 --> 99647 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.01
External database links:  
ASAP:
 ABE-0000320
CGSC:
 30409
ECHOBASE:
 EB0340
ECOLIHUB:
 ftsW
OU-MICROARRAY:
 b0089
STRING:
 511145.b0089
COLOMBOS: ftsW


Product      
Name: peptidoglycan glycosyltransferase FtsW
Synonym(s): FtsW, SEDS family protein FtsW, essential cell division protein FtsW
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 45.987
Isoelectric point: 10.218
Motif(s):
 
Type Positions Sequence
48 -> 68 LLWLTFGLAAIGFIMVTSASM
112 -> 132 ATMLLGSIILLMIVLVVGSSV
175 -> 194 LRGFLKPMGVILVLAVLLLA
311 -> 311 G
402 -> 402 R

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.1 - cell division
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0032153 - cell division site
molecular_function GO:0005515 - protein binding
GO:0016757 - glycosyltransferase activity
GO:0016740 - transferase activity
GO:0008955 - peptidoglycan glycosyltransferase activity
GO:0015648 - lipid-linked peptidoglycan transporter activity
biological_process GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0009252 - peptidoglycan biosynthetic process
GO:0043093 - FtsZ-dependent cytokinesis
GO:0008360 - regulation of cell shape
GO:0071555 - cell wall organization
GO:0015836 - lipid-linked peptidoglycan transport
Note(s): Note(s): ...[more].
Reference(s): [1] Ikeda M., et al., 1989
[2] Li Y., et al., 2021
[3] Liu X., et al., 2018
[4] Ovchinnikov S., et al., 2015
External database links:  
DIP:
 DIP-47989N
ECOCYC:
 EG10344-MONOMER
ECOLIWIKI:
 b0089
INTERPRO:
 IPR001182
INTERPRO:
 IPR013437
INTERPRO:
 IPR018365
MINT:
 P0ABG4
PANTHER:
 PTHR30474
PFAM:
 PF01098
PRIDE:
 P0ABG4
PRODB:
 PRO_000022723
PROSITE:
 PS00428
REFSEQ:
 NP_414631
UNIPROT:
 P0ABG4


Operon      
Name: mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC         
Operon arrangement:
Transcription unit        Promoter
mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
mraW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsQ
ftsQAZ
ftsQAZ
ftsAZ
ftsZ
ftsZ
ftsZ
lpxC
lpxC


Transcriptional Regulation      
Display Regulation             
Repressed by: MraZ, LexA, PdhR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_162 96153 forward nd [RS-EPT-CBR] [5]
  promoter TSS_163 (cluster) 96971 forward nd [RS-EPT-CBR] [5]
  promoter TSS_164 96982 forward nd [RS-EPT-CBR] [5]
  promoter TSS_165 96984 forward nd [RS-EPT-CBR] [5]
  promoter TSS_166 96988 forward nd [RS-EPT-CBR] [5]
  promoter TSS_167 96993 forward nd [RS-EPT-CBR] [5]
  promoter TSS_168 96997 forward nd [RS-EPT-CBR] [5]
  promoter TSS_169 97532 forward nd [RS-EPT-CBR] [5]
  promoter TSS_170 97539 forward nd [RS-EPT-CBR] [5]
  promoter TSS_171 97550 forward nd [RS-EPT-CBR] [5]
  promoter TSS_172 100621 forward nd [RS-EPT-CBR] [5]
  promoter TSS_173 (cluster) 102049 forward nd [RS-EPT-CBR] [5]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Ikeda M., Sato T., Wachi M., Jung HK., Ishino F., Kobayashi Y., Matsuhashi M., 1989, Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively., J Bacteriol 171(11):6375-8

 [2] Li Y., Gong H., Zhan R., Ouyang S., Park KT., Lutkenhaus J., Du S., 2021, Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes., PLoS Genet 17(4):e1009366

 [3] Liu X., Meiresonne NY., Bouhss A., den Blaauwen T., 2018, FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli., Mol Microbiol 109(6):855-884

 [4] Ovchinnikov S., Kinch L., Park H., Liao Y., Pei J., Kim DE., Kamisetty H., Grishin NV., Baker D., 2015, Large-scale determination of previously unsolved protein structures using evolutionary information., Elife 4:e09248

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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