RegulonDB

Gene
Name:	livH
Synonym(s):	ECK3441, EG10538, b3457, hrbB, hrbC, hrbD
Genome position(nucleotides):	3595477 <-- 3596403
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	56.2
External database links:

ASAP:	ABE-0011290
CGSC:	552
ECHOBASE:	EB0533
ECOLIHUB:	livH
OU-MICROARRAY:	b3457
STRING:	511145.b3457
COLOMBOS:	livH

Shine dalgarno
Sequence:	gggcgggtttAGAAAGgttacctTAT

Product

Name:

branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH

Synonym(s):

HrbB, HrbC, HrbD, LivH

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

32.982

Isoelectric point:

8.156

Motif(s):

Type	Positions	Sequence	Comment
	12 -> 292	MFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTGWLLVAAGFVGAIVIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWVVGHSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGIAEALSSAYLSTEYKDVVSFALLILVL
	22 -> 42	YALIAIGYTMVYGIIGMINFA	UniProt: Helical.
	46 -> 66	VYMIGSYVSFMIIAALMMMGI	UniProt: Helical.
	69 -> 89	GWLLVAAGFVGAIVIASAYGW	UniProt: Helical.
	105 -> 125	LIALISAIGMSIFLQNYVSLT	UniProt: Helical.

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.19 - leucine
		6 - cell structure --> 6.1 - membrane
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
	molecular_function	GO:0022857 - transmembrane transporter activity GO:0015192 - L-phenylalanine transmembrane transporter activity GO:0015658 - branched-chain amino acid transmembrane transporter activity GO:0005304 - L-valine transmembrane transporter activity GO:0015190 - L-leucine transmembrane transporter activity GO:0015188 - L-isoleucine transmembrane transporter activity
	biological_process	GO:1903806 - L-isoleucine import across plasma membrane GO:0006865 - amino acid transport GO:0015803 - branched-chain amino acid transport GO:0015823 - phenylalanine transport GO:0055085 - transmembrane transport GO:0015808 - L-alanine transport GO:0042941 - D-alanine transport GO:1903714 - isoleucine transmembrane transport GO:1903785 - L-valine transmembrane transport GO:0098713 - leucine import across plasma membrane

Note(s):

Note(s): ...[more].

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

livKHMGF

Operon arrangement:

Transcription unit	Promoter
livKHMGF	livKp2
livKHMGF	livKp1

Transcriptional Regulation
	Display Regulation
Repressed by:	Lrp

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_4058	3596577		reverse	nd	[RS-EPT-CBR]	[1]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.