RegulonDB

Gene
Name:	livM
Synonym(s):	ECK3440, EG10541, b3456
Genome position(nucleotides):	3594203 <-- 3595480
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	56.57
External database links:

ASAP:	ABE-0011287
CGSC:	18190
ECHOBASE:	EB0536
ECOLIHUB:	livM
OU-MICROARRAY:	b3456
STRING:	511145.b3456
COLOMBOS:	livM

Shine dalgarno
Sequence:	ctgggtcgccCGGAGGtagagaaagTAT

Product

Name:

branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM

Synonym(s):

LivM

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

46.269

Isoelectric point:

10.087

Motif(s):

Type	Positions	Sequence	Comment
	6 -> 26	IAMALLSAAMFFVLAGVFMGV	UniProt: Helical.
	45 -> 65	WQWVFIGTAVVFFFQLLRPAF	UniProt: Helical.
	92 -> 112	FLVALLVLAVAWPFMVSRGTV	UniProt: Helical.
	112 -> 398	VDIATLTMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYTFALLNHYYGLGFWTCLPIAGLMAAAAGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAREGGWDTFSNFFGLKYDPSDRVIFLYLVALLLVVLSLFVINRLLRMPLGRAWEALREDEIACRSLGLSPRRIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFAESAFVLAIVVLGGMGSQFAVILAAILLVVSRELMRDFNEYSMLMLGGLMVLMM
	120 -> 140	IYIILGLGLNVVVGLSGLLVL	UniProt: Helical.

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.19 - leucine
		6 - cell structure --> 6.1 - membrane
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
	molecular_function	GO:0022857 - transmembrane transporter activity GO:0015192 - L-phenylalanine transmembrane transporter activity GO:0015658 - branched-chain amino acid transmembrane transporter activity GO:0005304 - L-valine transmembrane transporter activity GO:0015190 - L-leucine transmembrane transporter activity GO:0015188 - L-isoleucine transmembrane transporter activity
	biological_process	GO:0006865 - amino acid transport GO:0015803 - branched-chain amino acid transport GO:0015823 - phenylalanine transport GO:0055085 - transmembrane transport GO:1903714 - isoleucine transmembrane transport GO:1903785 - L-valine transmembrane transport GO:0098713 - leucine import across plasma membrane

Note(s):

Note(s): ...[more].

Reference(s):

[1] Jindal S., et al., 2019
[2] Nazos PM., et al., 1985

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

livKHMGF

Operon arrangement:

Transcription unit	Promoter
livKHMGF	livKp2
livKHMGF	livKp1

Transcriptional Regulation
	Display Regulation
Repressed by:	Lrp

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_4058	3596577		reverse	nd	[RS-EPT-CBR]	[3]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195
[2] Nazos PM., Mayo MM., Su TZ., Anderson JJ., Oxender DL., 1985, Identification of livG, a membrane-associated component of the branched-chain amino acid transport in Escherichia coli., J Bacteriol 163(3):1196-202
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.