RegulonDB RegulonDB 10.9: Gene Form
   

malZ gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

malZ proY acpH MalT MalT MalT malZp malZp

Gene      
Name: malZ    Texpresso search in the literature
Synonym(s): ECK0397, EG10565, b0403
Genome position(nucleotides): 422518 --> 424332 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.6
External database links:  
ASAP:
 ABE-0001402
CGSC:
 29868
ECHOBASE:
 EB0560
ECOLIHUB:
 malZ
OU-MICROARRAY:
 b0403
STRING:
 511145.b0403
COLOMBOS: malZ


Shine dalgarno      
Sequence: attttcatcaCAGGGGaattatgATG


Product      
Name: maltodextrin glucosidase
Synonym(s): MalZ
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 69.041
Isoelectric point: 6.364
Motif(s):
 
Type Positions Sequence
546 -> 546 R
445 -> 445 D
177 -> 493 GDLDGISEKLPYLKKLGVTALYLNPVFKAPSVHKYDTEDYRHVDPQFGGDGALLRLRHNTQQLGMRLVLDGVFNHSGDSHAWFDRHNRGTGGACHNPESPWRDWYSFSDDGTALDWLGYASLPKLDYQSESLVNEIYRGEDSIVRHWLKAPWNMDGWRLDVVHMLGEAGGARNNMQHVAGITEAAKETQPEAYIVGEHFGDARQWLQADVEDAAMNYRGFTFPLWGFLANTDISYDPQQIDAQTCMAWMDNYRAGLSHQQQLRMFNQLDSHDTARFKTLLGRDIARLPLAVVWLFTWPGVPCIYYGDEVGLDGKNDP
301 -> 301 L
1 -> 104 MLNAWHLPVPPFVKQSKDQLLITLWLTGEDPPQRIMLRTEHDNEEMSVPMHKQRSQPQPGVTAWRAAIDLSSGQPRRRYSFKLLWHDRQRWFTPQGFSRMPPAR

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.4 - polysaccharides
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016787 - hydrolase activity
GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 - hydrolase activity, acting on glycosyl bonds
GO:0004558 - alpha-1,4-glucosidase activity
GO:0032450 - maltose alpha-glucosidase activity
GO:0090599 - alpha-glucosidase activity
biological_process GO:0008152 - metabolic process
GO:0005975 - carbohydrate metabolic process
GO:0000023 - maltose metabolic process
GO:0030980 - alpha-glucan catabolic process
GO:0051692 - cellular oligosaccharide catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Goyal M., et al., 2015
[2] Jain N., et al., 2018
[3] Said-Salman IH., et al., 2019
External database links:  
CAZY:
 GH13
CAZY:
 CBM34
DIP:
 DIP-10152N
ECOCYC:
 MALTODEXGLUCOSID-MONOMER
ECOLIWIKI:
 b0403
INTERPRO:
 IPR004185
INTERPRO:
 IPR006047
INTERPRO:
 IPR017853
INTERPRO:
 IPR013780
INTERPRO:
 IPR014756
INTERPRO:
 IPR017069
MINT:
 P21517
MODBASE:
 P21517
PDB:
 5BN7
PFAM:
 PF00128
PFAM:
 PF02903
PRIDE:
 P21517
PRODB:
 PRO_000023158
REFSEQ:
 NP_414937
SMART:
 SM00642
SMR:
 P21517
UNIPROT:
 P21517


Operon      
Name: malZ         
Operon arrangement:
Transcription unit        Promoter
malZ


Transcriptional Regulation      
Display Regulation             
Activated by: MalT


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Goyal M., Chaudhuri TK., 2015, GroEL-GroES assisted folding of multiple recombinant proteins simultaneously over-expressed in Escherichia coli., Int J Biochem Cell Biol 64:277-86

 [2] Jain N., Knowles TJ., Lund PA., Chaudhuri TK., 2018, Minichaperone (GroEL191-345) mediated folding of MalZ proceeds by binding and release of native and functional intermediates., Biochim Biophys Acta Proteins Proteom 1866(9):941-951

 [3] Said-Salman IH., Jebaii FA., Yusef HH., Moustafa ME., 2019, Global gene expression analysis of Escherichia coli K-12 DH5α after exposure to 2.4 GHz wireless fidelity radiation., Sci Rep 9(1):14425

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