RegulonDB

Gene
Name:	mglC
Synonym(s):	ECK2141, EG10594, b2148, mglP
Genome position(nucleotides):	2236743 <-- 2237753 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.25
External database links:

ASAP:	ABE-0007101
CGSC:	500
ECHOBASE:	EB0589
ECOLIHUB:	mglC
OU-MICROARRAY:	b2148
STRING:	511145.b2148
COLOMBOS:	mglC

Product

Name:

D-galactose/methyl-galactoside ABC transporter membrane subunit

Synonym(s):

MglC, MglP

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

35.55

Isoelectric point:

9.282

Motif(s):

Type	Positions	Sequence
	42 -> 324	LSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAVVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPISGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGVFYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAIIIFA
	306 -> 326	IGVNPYWQYIIKGAIIIFAVA
	53 -> 73	IIIALGVAGLIVTQGTDLSAG
	17 -> 37	GIYVVLLVLLAIIIFQDPTFL
	107 -> 127	LVILIVCAIGAVIGLINGLII

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
		6 - cell structure --> 6.1 - membrane
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane GO:0043190 - ATP-binding cassette (ABC) transporter complex
	molecular_function	GO:0005354 - galactose transmembrane transporter activity GO:0022857 - transmembrane transporter activity GO:0015592 - methylgalactoside transmembrane transporter activity
	biological_process	GO:0006974 - cellular response to DNA damage stimulus GO:0008643 - carbohydrate transport GO:0015757 - galactose transmembrane transport GO:0055085 - transmembrane transport GO:0015765 - methylgalactoside transport

Note(s):

Note(s): ...[more].

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

mglBAC

Operon arrangement:

Transcription unit	Promoter
mglAC	mglAp
mglBAC	mglBp
mglBAC	mglBp2

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	GalS, FlhDC, GalR, Fis

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	mglCp5	2237858	reverse	nd	[ICWHO]	[1]
promoter	mglCp9	2237923	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.45. P-value: 2.254e-5 It was suggested that this predicted promoter does not exist, because its activity was not observed during σE induction in high-throughput analysis Lacoux C,2020. Read more >	[ICWHO]	[1]
promoter	mglCp6	2237959	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 2.99. P-value: 8.028e-5 It was suggested that this predicted promoter does not exist, because its activity was not observed during σE induction in high-throughput analysis Lacoux C,2020. Read more >	[ICWHO]	[1]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78