RegulonDB

Gene
Name:	mglC
Synonym(s):	ECK2141, EG10594, b2148, mglP
Genome position(nucleotides):	2236743 <-- 2237753 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.25
External database links:

ASAP:	ABE-0007101
CGSC:	500
ECHOBASE:	EB0589
ECOLIHUB:	mglC
OU-MICROARRAY:	b2148
STRING:	511145.b2148
COLOMBOS:	mglC

Product

Name:

D-galactose/methyl-galactoside ABC transporter membrane subunit

Synonym(s):

MglC, MglP

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

35.55

Isoelectric point:

9.282

Motif(s):

Type	Positions	Sequence
	42 -> 324	LSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAVVAATLLQSMDNANKVFPEMATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFITTLGTMIIVYGINSLYYDFVGASPISGFDSGFSTFAQGFVALGSFRLSYITFYALIAVAFVWVLWNKTRFGKNIFAIGGNPEAAKVSGVNVGLNLLMIYALSGVFYAFGGMLEAGRIGSATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAIIIFA
	306 -> 326	IGVNPYWQYIIKGAIIIFAVA
	53 -> 73	IIIALGVAGLIVTQGTDLSAG
	17 -> 37	GIYVVLLVLLAIIIFQDPTFL
	107 -> 127	LVILIVCAIGAVIGLINGLII

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
		6 - cell structure --> 6.1 - membrane
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane GO:0043190 - ATP-binding cassette (ABC) transporter complex
	molecular_function	GO:0005354 - galactose transmembrane transporter activity GO:0022857 - transmembrane transporter activity GO:0015592 - methylgalactoside transmembrane transporter activity
	biological_process	GO:0006974 - cellular response to DNA damage stimulus GO:0008643 - carbohydrate transport GO:0015757 - galactose transmembrane transport GO:0055085 - transmembrane transport GO:0015765 - methylgalactoside transport

Note(s):

Note(s): ...[more].

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

mglBAC

Operon arrangement:

Transcription unit	Promoter
mglAC	mglAp
mglBAC	mglBp
mglBAC	mglBp2

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	GalS, FlhDC, GalR, Fis

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	mglCp5	2237858	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 2.985. P-value: 8.440e-5 Read more >	[ICWHO]	[1]
promoter	mglCp9	2237923	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.45. P-value: 2.254e-5 It was suggested that this predicted promoter does not exist, because its activity was not observed during σE induction in high-throughput analysis Lacoux C,2020. Read more >	[ICWHO]	[1]
promoter	mglCp6	2237959	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 2.99. P-value: 8.028e-5 It was suggested that this predicted promoter does not exist, because its activity was not observed during σE induction in high-throughput analysis Lacoux C,2020. Read more >	[ICWHO]	[1]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78