RegulonDB RegulonDB 10.10: Gene Form
   

mraY gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

murE murF murD mraY ftsI TSS_171 TSS_171 TSS_170 TSS_170 TSS_169 TSS_169 TSS_168 TSS_168 TSS_167 TSS_167 TSS_166 TSS_166 TSS_165 TSS_165 TSS_164 TSS_164 TSS_163 (cluster) TSS_163 (cluster) TSS_162 TSS_162 TSS_161 (cluster) TSS_161 (cluster) TSS_160 TSS_160

Gene      
Name: mraY    Texpresso search in the literature
Synonym(s): ECK0088, EG10604, b0087, murX
Genome position(nucleotides): 96002 --> 97084 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.37
External database links:  
ASAP:
 ABE-0000316
CGSC:
 30466
ECHOBASE:
 EB0599
ECOLIHUB:
 mraY
OU-MICROARRAY:
 b0087
STRING:
 511145.b0087
COLOMBOS: mraY


Product      
Name: phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonym(s): MraY, MurX
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 39.875
Isoelectric point: 9.984
Motif(s):
 
Type Positions Sequence
271 -> 284 LALGGALGIIAVLL
19 -> 45 FSYLTFRAIVSLLTALFISLWMGPRMI
239 -> 251 LVIVCTAIVGAGL
342 -> 357 FWIISLMLVLIGLATL
174 -> 188 LFYILLAYFVIVGTG

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.7 - murein (peptidoglycan)
  6 - cell structure --> 6.1 - membrane
  6 - cell structure --> 6.2 - murein
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016740 - transferase activity
GO:0016780 - phosphotransferase activity, for other substituted phosphate groups
GO:0008963 - phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0051992 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
biological_process GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0009252 - peptidoglycan biosynthetic process
GO:0008360 - regulation of cell shape
GO:0044038 - cell wall macromolecule biosynthetic process
GO:0071555 - cell wall organization
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 PHOSNACMURPENTATRANS-MONOMER
ECOLIWIKI:
 b0087
INTERPRO:
 IPR018480
INTERPRO:
 IPR000715
INTERPRO:
 IPR003524
PANTHER:
 PTHR22926
PFAM:
 PF00953
PFAM:
 PF10555
PRIDE:
 P0A6W3
PRODB:
 PRO_000023283
PROSITE:
 PS01347
PROSITE:
 PS01348
REFSEQ:
 NP_414629
SMR:
 P0A6W3
UNIPROT:
 P0A6W3


Operon      
Name: mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC         
Operon arrangement:
Transcription unit        Promoter
mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
mraW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsQ
ftsQAZ
ftsQAZ
ftsAZ
ftsZ
ftsZ
ftsZ
lpxC
lpxC


Transcriptional Regulation      
Display Regulation             
Repressed by: MraZ, LexA, PdhR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_160 94608 forward nd [RS-EPT-CBR] [1]
  promoter TSS_161 (cluster) 94681 forward nd [RS-EPT-CBR] [1]
  promoter TSS_162 96153 forward nd [RS-EPT-CBR] [1]
  promoter TSS_163 (cluster) 96971 forward nd [RS-EPT-CBR] [1]
  promoter TSS_164 96982 forward nd [RS-EPT-CBR] [1]
  promoter TSS_165 96984 forward nd [RS-EPT-CBR] [1]
  promoter TSS_166 96988 forward nd [RS-EPT-CBR] [1]
  promoter TSS_167 96993 forward nd [RS-EPT-CBR] [1]
  promoter TSS_168 96997 forward nd [RS-EPT-CBR] [1]
  promoter TSS_169 97532 forward nd [RS-EPT-CBR] [1]
  promoter TSS_170 97539 forward nd [RS-EPT-CBR] [1]
  promoter TSS_171 97550 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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