RegulonDB RegulonDB 10.10: Gene Form
   

narX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

narX ychO narK narL nc3 ModE FNR Fis FNR NarL FNR FNR NarL NarL NarL NarL IHF NarL NarL NarL NarL NarL FNR narKp1 narKp1 narKp2 narKp2 narXp narXp

Gene      
Name: narX    Texpresso search in the literature
Synonym(s): ECK1216, EG10646, b1222, frd1, frdR, narR
Genome position(nucleotides): 1275822 <-- 1277618 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.37
External database links:  
ASAP:
 ABE-0004099
CGSC:
 18106
ECHOBASE:
 EB0640
ECOLIHUB:
 narX
OU-MICROARRAY:
 b1222
STRING:
 511145.b1222
COLOMBOS: narX


Shine dalgarno      
Sequence: aaagcctgaaGGAAGAggtttaCAT


Product      
Name: sensor histidine kinase NarX
Synonym(s): FrdR, NarR, NarX
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 67.084
Isoelectric point: 6.722
Motif(s):
 
Type Positions Sequence
15 -> 37 VALIVLLSTAIGLAGMAVSGWLV
49 -> 49 K
252 -> 252 W
390 -> 453 ERATIARELHDSIAQSLSCMKMQVSCLQMQGDALPESSRELLSQIRNELNASWAQLRELLTTFR
393 -> 587 TIARELHDSIAQSLSCMKMQVSCLQMQGDALPESSRELLSQIRNELNASWAQLRELLTTFRLQLTEPGLRPALEASCEEYSAKFGFPVKLDYQLPPRLVPSHQAIHLLQIAREALSNALKHSQASEVVVTVAQNDNQVKLTVQDNGCGVPENAIRSNHYGMIIMRDRAQSLRGDCRVRRRESGGTEVVVTFIPEK

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0004721 - phosphoprotein phosphatase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0000155 - phosphorelay sensor kinase activity
GO:0004673 - protein histidine kinase activity
GO:0042803 - protein homodimerization activity
GO:0046983 - protein dimerization activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0006470 - protein dephosphorylation
GO:0016310 - phosphorylation
GO:0000160 - phosphorelay signal transduction system
GO:0007165 - signal transduction
GO:0046777 - protein autophosphorylation
GO:0018106 - peptidyl-histidine phosphorylation
GO:0042128 - nitrate assimilation
GO:0071249 - cellular response to nitrate
GO:0071250 - cellular response to nitrite
External database links:  
DIP:
 DIP-35785N
ECOCYC:
 NARX-MONOMER
ECOLIWIKI:
 b1222
INTERPRO:
 IPR005467
INTERPRO:
 IPR042295
INTERPRO:
 IPR036890
INTERPRO:
 IPR003594
INTERPRO:
 IPR003660
INTERPRO:
 IPR011712
INTERPRO:
 IPR016380
INTERPRO:
 IPR029095
MODBASE:
 P0AFA2
PDB:
 3EZH
PDB:
 3EZI
PFAM:
 PF13675
PFAM:
 PF07730
PFAM:
 PF02518
PFAM:
 PF00672
PRIDE:
 P0AFA2
PRODB:
 PRO_000023362
PROSITE:
 PS50109
PROSITE:
 PS50885
REFSEQ:
 NP_415740
SMART:
 SM00387
SMART:
 SM00304
SMR:
 P0AFA2
UNIPROT:
 P0AFA2


Operon      
Name: narXL         
Operon arrangement:
Transcription unit        Promoter
narXL


Transcriptional Regulation      
Display Regulation             
Activated by: ModE
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB