RegulonDB RegulonDB 10.9: Gene Form
   

pgi gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pgi lysC yjbE IHF RcsAB SoxS Cis-reg; riboswitch yjbEp2 yjbEp2 yjbEp1 yjbEp1 TSS_4871 TSS_4871 TSS_4870 TSS_4870 TSS_4869 TSS_4869 TSS_4868 TSS_4868 TSS_4867 (cluster) TSS_4867 (cluster) TSS_4866 (cluster) TSS_4866 (cluster) TSS_4865 TSS_4865 TSS_4864 TSS_4864 TSS_4863 TSS_4863 pgip pgip lysCp2 lysCp2 lysCp1 lysCp1 TSS_4862 TSS_4862 TSS_4861 TSS_4861 TSS_4860 TSS_4860 TSS_4859 TSS_4859 TSS_4858 TSS_4858 TSS_4857 TSS_4857 TSS_4856 TSS_4856 TSS_4855 TSS_4855 TSS_4854 TSS_4854 TSS_4853 TSS_4853 TSS_4852 (cluster) TSS_4852 (cluster) TSS_4851 TSS_4851 TSS_4850 TSS_4850 TSS_4849 TSS_4849 TSS_4848 TSS_4848 TSS_4847 TSS_4847

Gene      
Name: pgi    Texpresso search in the literature
Synonym(s): ECK4017, EG10702, b4025
Genome position(nucleotides): 4233758 --> 4235407 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.33
External database links:  
ASAP:
ABE-0013163
CGSC:
409
ECHOBASE:
EB0696
ECOLIHUB:
pgi
MIM:
613470
OU-MICROARRAY:
b4025
STRING:
511145.b4025
COLOMBOS: pgi


Product      
Name: glucose-6-phosphate isomerase
Synonym(s): Pgi
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 61.53
Isoelectric point: 6.237
Motif(s):
 
Type Positions Sequence
52 -> 541 DYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLI
317 -> 317 L

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.1 - glycolysis
  1 - metabolism --> 1.7 - central intermediary metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016853 - isomerase activity
GO:0004347 - glucose-6-phosphate isomerase activity
GO:0048029 - monosaccharide binding
GO:0042802 - identical protein binding
GO:0042803 - protein homodimerization activity
biological_process GO:0006094 - gluconeogenesis
GO:0006096 - glycolytic process
GO:0034599 - cellular response to oxidative stress
GO:0051156 - glucose 6-phosphate metabolic process
External database links:  
DIP:
DIP-35887N
ECOCYC:
PGLUCISOM
ECOLIWIKI:
b4025
INTERPRO:
IPR035476
INTERPRO:
IPR018189
INTERPRO:
IPR001672
INTERPRO:
IPR023096
INTERPRO:
IPR035482
MODBASE:
P0A6T1
PANTHER:
PTHR11469
PDB:
3NBU
PFAM:
PF00342
PRIDE:
P0A6T1
PRINTS:
PR00662
PRODB:
PRO_000025181
PROSITE:
PS51463
PROSITE:
PS00765
PROSITE:
PS00174
REFSEQ:
NP_418449
SMR:
P0A6T1
SWISSMODEL:
P0A6T1
UNIPROT:
P0A6T1


Operon      
Name: pgi         
Operon arrangement:
Transcription unit        Promoter
pgi
pgi


Transcriptional Regulation      
Display Regulation             
Activated by: SoxS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4847 4233084 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4848 4233093 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4849 4233095 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4850 4233097 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4851 4233099 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4852 (cluster) 4233115 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_4853 4233120 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4854 4233132 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4855 4233151 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4856 4233231 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4857 4233233 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4858 4233235 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4859 4233254 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4860 4233281 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4861 4233289 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4862 4233537 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4863 4233952 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4864 4233960 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4865 4234102 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4866 (cluster) 4234157 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_4867 (cluster) 4234160 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_4868 4234163 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4869 4234180 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4870 4234624 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4871 4235143 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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