RegulonDB RegulonDB 11.1: Gene Form
   

pheP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cusA pheP ybdG terminator anti-terminator anti-anti-terminator phePp phePp TSS_719 TSS_719 TSS_718 TSS_718

Gene      
Name: pheP    Texpresso search in the literature
Synonym(s): ECK0568, EG10708, b0576
Genome position(nucleotides): 601959 --> 603335
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.51
External database links:  
ASAP:
 ABE-0001976
CGSC:
 402
ECHOBASE:
 EB0702
ECOLIHUB:
 pheP
OU-MICROARRAY:
 b0576
STRING:
 511145.b0576
COLOMBOS: pheP


Product      
Name: phenylalanine:H+ symporter PheP
Synonym(s): PheP, PheP phenylalanine APC transporter
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 50.677
Isoelectric point: 9.78
Motif(s):
 
Type Positions Sequence Comment
27 -> 448 HIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFL
28 -> 48 IQLIALGGAIGTGLFLGIGPA UniProt: Helical; Name=I.
51 -> 71 MAGPAVLLGYGVAGIIAFLIM UniProt: Helical; Name=II.
106 -> 126 NYWVMFVLVGMAELTAAGIYM UniProt: Helical; Name=III.
133 -> 153 VPTWIWAAAFFIIINAVNLVN UniProt: Helical; Name=IV.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.13 - phenylalanine
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0006865 - amino acid transport
GO:0015823 - phenylalanine transport
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P24207
DIP:
 DIP-10479N
ECOCYC:
 PHEP-MONOMER
ECOLIWIKI:
 b0576
INTERPRO:
 IPR004840
INTERPRO:
 IPR004841
PFAM:
 PF00324
PRIDE:
 P24207
PRODB:
 PRO_000023529
PROSITE:
 PS00218
REFSEQ:
 NP_415108
UNIPROT:
 P24207


Operon      
Name: pheP         
Operon arrangement:
Transcription unit        Promoter
pheP


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_718 599136 forward nd [RS-EPT-CBR] [1]
  promoter TSS_719 600284 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB