RegulonDB RegulonDB 10.10: Gene Form
   

tldE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tldE yjgA nrdG cybC anti-anti-terminator anti-terminator terminator terminator yjgAp5 yjgAp5 yjgAp9 yjgAp9 yjgAp11 yjgAp11 yjgAp8 yjgAp8 tldEp tldEp TSS_5084 TSS_5084

Gene      
Name: tldE    Texpresso search in the literature
Synonym(s): ECK4230, EG10741, b4235, mcb, pmbA
Genome position(nucleotides): 4457959 --> 4459311 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
54.25
External database links:  
ASAP:
ABE-0013854
CGSC:
34577
ECHOBASE:
EB0734
ECOLIHUB:
pmbA
OU-MICROARRAY:
b4235
STRING:
511145.b4235
COLOMBOS: tldE


Product      
Name: metalloprotease subunit TldE
Synonym(s): Mcb, PmbA, TldE, protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 48.37
Isoelectric point: 5.321
Motif(s):
 
Type Positions Sequence
36 -> 326 AEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVYHQNRKGSASSTDLSPQAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQAALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYAYTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAGGSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDIIKDGILTQ

 

Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  5 - cell processes --> 5.6 - protection --> 5.6.3 - cell killing
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:1905368 - peptidase complex
molecular_function GO:0005515 - protein binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0008237 - metallopeptidase activity
biological_process GO:0006508 - proteolysis
GO:0016485 - protein processing
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-47844N
ECOCYC:
EG10741-MONOMER
ECOLIWIKI:
b4235
INTERPRO:
IPR036059
INTERPRO:
IPR002510
INTERPRO:
IPR035068
PDB:
5NJF
PDB:
5NJC
PDB:
5NJB
PDB:
5NJA
PDB:
5NJ9
PDB:
5NJ5
PFAM:
PF01523
PRIDE:
P0AFK0
PRODB:
PRO_000023558
REFSEQ:
NP_418656
SMR:
P0AFK0
SWISSMODEL:
P0AFK0
UNIPROT:
P0AFK0


Operon      
Name: tldE         
Operon arrangement:
Transcription unit        Promoter
tldE


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_5084 4457943 forward nd [RS-EPT-CBR] [1]
  promoter yjgAp8 4458015 reverse nd [ICWHO] [2]
  promoter yjgAp11 4458046 reverse nd [ICWHO] [2]
  promoter yjgAp9 4458065 reverse nd [ICWHO] [2]
  promoter yjgAp5 4458081 reverse nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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