Gene
Name:	purM
Synonym(s):	ECK2495, EG10798, b2499, purG, purI
Genome position(nucleotides):	2621197 --> 2622234 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.89
Reference(s):	[1] Smith JM., et al., 1986
External database links:

ASAP:	ABE-0008230
CGSC:	335
ECHOBASE:	EB0791
ECOLIHUB:	purM
OU-MICROARRAY:	b2499
STRING:	511145.b2499
COLOMBOS:	purM

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_2780	2620986	reverse	nd	[RS-EPT-CBR]	[2]
promoter	ppkp5	2622874	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 7.446. P-value: 3.144e-6 Read more >	[ICWHO]	[3]
promoter	ppkp6	2622990	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 7.65. P-value: 2.353e-6 Read more >	[ICWHO]	[3]
promoter	TSS_2781 (cluster)	2625007	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 2625007 to 2625008, where the highest frequency is at position 2623030. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	TSS_2782 (cluster)	2625014	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 2625014 to 2625015, where the highest frequency is at position 2623036. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Smith JM., Daum HA., 1986, Nucleotide sequence of the purM gene encoding 5'-phosphoribosyl-5-aminoimidazole synthetase of Escherichia coli K12., J Biol Chem 261(23):10632-6
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Transcriptional Regulation
	Display Regulation
Repressed by:	PurR, FNR