RegulonDB

Gene
Name:	soxS
Synonym(s):	ECK4054, EG10958, b4062
Genome position(nucleotides):	4277060 <-- 4277383
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.93
External database links:

ASAP:	ABE-0013311
CGSC:	27801
ECHOBASE:	EB0951
ECOLIHUB:	soxS
OU-MICROARRAY:	b4062
STRING:	511145.b4062
COLOMBOS:	soxS

Shine dalgarno
Sequence:	tgaacactgaAAAGAGgcagattTAT

Product

Name:

DNA-binding transcriptional dual regulator SoxS

Synonym(s):

SoxS, regulation of superoxide response regulon

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

AraC/XylS

Cellular location:

cytosol

Molecular weight:

12.911

Isoelectric point:

10.277

Motif(s):

Type	Positions	Sequence	Comment
	2 -> 107	SHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL	UniProt: Regulatory protein SoxS.
	8 -> 106	QDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHR	UniProt: HTH araC/xylS-type.
	25 -> 46	DVVAKKSGYSKWYLQRMFRTVT	UniProt: H-T-H motif.
	27 -> 106	VAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHR
	73 -> 96	IFDIAMDLGYVSQQTFSRVFRRQF	UniProt: H-T-H motif.

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.2 - regulon
		5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
		5 - cell processes --> 5.6 - protection --> 5.6.2 - detoxification
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0043565 - sequence-specific DNA binding GO:0000987 - cis-regulatory region sequence-specific DNA binding GO:0001108 - bacterial-type RNA polymerase holo enzyme binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[EXP] Inferred from experiment

Reference(s):

[1] Amabile-Cuevas CF., et al., 1991
[2] Blattner FR., et al., 1993
[3] Fawcett WP., et al., 1994
[4] Fawcett WP., et al., 1995
[5] Li Z., et al., 1994
[6] Nunoshiba T., et al., 1993
[7] Wu J., et al., 1991

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

SWISSMODEL:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	SoxR
Repressed by:	Fur, FNR, SoxS, AcrR

Reference(s)
[1] Amabile-Cuevas CF., Demple B., 1991, Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon., Nucleic Acids Res 19(16):4479-84
[2] Blattner FR., Burland V., Plunkett G., Sofia HJ., Daniels DL., 1993, Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes., Nucleic Acids Res 21(23):5408-17
[3] Fawcett WP., Wolf RE., 1994, Purification of a MalE-SoxS fusion protein and identification of the control sites of Escherichia coli superoxide-inducible genes., Mol Microbiol 14(4):669-79
[4] Fawcett WP., Wolf RE., 1995, Genetic definition of the Escherichia coli zwf "soxbox," the DNA binding site for SoxS-mediated induction of glucose 6-phosphate dehydrogenase in response to superoxide., J Bacteriol 177(7):1742-50
[5] Li Z., Demple B., 1994, SoxS, an activator of superoxide stress genes in Escherichia coli. Purification and interaction with DNA., J Biol Chem 269(28):18371-7
[6] Nunoshiba T., Hidalgo E., Li Z., Demple B., 1993, Negative autoregulation by the Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response., J Bacteriol 175(22):7492-4
[7] Wu J., Weiss B., 1991, Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli., J Bacteriol 173(9):2864-71