RegulonDB RegulonDB 10.9: Gene Form
   

sppA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

sppA ansA ydjA terminator anti-anti-terminator anti-terminator TSS_2076 TSS_2076 TSS_2075 TSS_2075 TSS_2074 TSS_2074 sppAp6 sppAp6 TSS_2073 TSS_2073 ydjAp ydjAp

Gene      
Name: sppA    Texpresso search in the literature
Synonym(s): ECK1764, EG10968, b1766
Genome position(nucleotides): 1848837 --> 1850693 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.75
External database links:  
ASAP:
 ABE-0005880
CGSC:
 13763
ECHOBASE:
 EB0961
ECOLIHUB:
 sppA
OU-MICROARRAY:
 b1766
STRING:
 511145.b1766
COLOMBOS: sppA


Product      
Name: protease IV, a signal peptide peptidase
Synonym(s): SppA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 67.219
Isoelectric point: 5.804
Motif(s):
 
Type Positions Sequence
410 -> 410 G
209 -> 209 K
378 -> 378 S
409 -> 409 S
151 -> 151 V

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0004175 - endopeptidase activity
GO:0008236 - serine-type peptidase activity
biological_process GO:0006508 - proteolysis
GO:0006465 - signal peptide processing
External database links:  
ECOCYC:
 EG10968-MONOMER
ECOLIWIKI:
 b1766
ECOO157CYC:
 SPPA-MONOMER
INTERPRO:
 IPR033854
INTERPRO:
 IPR002142
INTERPRO:
 IPR004634
INTERPRO:
 IPR004635
INTERPRO:
 IPR029045
MODBASE:
 P08395
PDB:
 3BEZ
PDB:
 3BF0
PFAM:
 PF01343
PRIDE:
 P08395
PRODB:
 PRO_000023978
REFSEQ:
 NP_416280
SMR:
 P08395
UNIPROT:
 P08395


Operon      
Name: sppA         
Operon arrangement:
Transcription unit        Promoter
sppA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2073 1848701 reverse nd [RS-EPT-CBR] [1]
  promoter sppAp6 1848711 forward Similarity to the consensus
Read more > 		[ICWHO] [2]
  promoter TSS_2074 1848792 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2075 1851179 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2076 1851322 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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