Gene
Name:	tnaA
Synonym(s):	ECK3701, EG11005, b3708, ind, tnaR
Genome position(nucleotides):	3888730 --> 3890145 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.85
External database links:

ASAP:	ABE-0012133
CGSC:	101
ECHOBASE:	EB0998
ECOLIHUB:	tnaA
NCBI-GENE:	948221
OU-MICROARRAY:	b3708
STRING:	511145.b3708
COLOMBOS:	tnaA

Reference(s)
[1] Boon N., Kaur M., Aziz A., Bradnick M., Shibayama K., Eguchi Y., Lund PA., 2020, The Signaling Molecule Indole Inhibits Induction of the AR2 Acid Resistance System in Escherichia coli., Front Microbiol 11:474
[2] Chong H., Geng H., Zhang H., Song H., Huang L., Jiang R., 2014, Enhancing E. coli isobutanol tolerance through engineering its global transcription factor cAMP receptor protein (CRP)., Biotechnol Bioeng 111(4):700-8
[3] Chu HY., Sprouffske K., Wagner A., 2017, The role of recombination in evolutionary adaptation of Escherichia coli to a novel nutrient., J Evol Biol 30(9):1692-1711
[4] Geng H., Jiang R., 2015, cAMP receptor protein (CRP)-mediated resistance/tolerance in bacteria: mechanism and utilization in biotechnology., Appl Microbiol Biotechnol 99(11):4533-43
[5] Gutierrez-Huante M., Martinez-Duncker ME., Sauceda E., Sanchez J., 2019, The antibiotics potentiator bicarbonate causes upregulation of tryptophanase and iron acquisition proteins in Escherichia coli., Lett Appl Microbiol 68(1):87-95
[6] Han TH., Lee JH., Cho MH., Wood TK., Lee J., 2011, Environmental factors affecting indole production in Escherichia coli., Res Microbiol 162(2):108-16
[7] Kanda T., Abiko G., Kanesaki Y., Yoshikawa H., Iwai N., Wachi M., 2020, RNase E-dependent degradation of tnaA mRNA encoding tryptophanase is prerequisite for the induction of acid resistance in Escherichia coli., Sci Rep 10(1):7128
[8] Liu J., Summers D., 2017, Indole at low concentration helps exponentially growing Escherichia coli survive at high temperature., PLoS One 12(12):e0188853
[9] Liu L., Liu Y., Zhang G., Ge Y., Fan X., Lin F., Wang J., Zheng H., Xie X., Zeng X., Chen PR., 2018, Genetically Encoded Chemical Decaging in Living Bacteria., Biochemistry 57(4):446-450
[10] Liu S., Wu N., Zhang S., Yuan Y., Zhang W., Zhang Y., 2017, Variable Persister Gene Interactions with (p)ppGpp for Persister Formation in Escherichia coli., Front Microbiol 8:1795
[11] Masuda Y., Sakamoto E., Honjoh KI., Miyamoto T., 2020, Role of Toxin-Antitoxin-Regulated Persister Population and Indole in Bacterial Heat Tolerance., Appl Environ Microbiol 86(16)
[12] Pringle SL., Palmer KL., McLean RJ., 2017, Indole production provides limited benefit to Escherichia coli during co-culture with Enterococcus faecalis., Arch Microbiol 199(1):145-153
[13] Taylor HV., Yudkin MD., 1978, Synthesis of tryptophanase in Escherichia coli: isolation and characterization of a structural-gene mutant and two regulatory mutants., Mol Gen Genet 165(1):95-102
[14] Wu Y., Chen J., Liu Z., Wang F., 2018, Identification of pyridoxal phosphate-modified proteins using mass spectrometry., Rapid Commun Mass Spectrom 32(3):195-200

Transcriptional Regulation
	Display Regulation
Activated by:	CRP, TorR