RegulonDB RegulonDB 10.10: Gene Form
   

uhpB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

uhpB uhpC uhpA ilvN CRP anti-terminator terminator TSS_4250 TSS_4250 uhpBp uhpBp

Gene      
Name: uhpB    Texpresso search in the literature
Synonym(s): ECK3659, EG11052, b3668
Genome position(nucleotides): 3848634 <-- 3850136 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 57.09
External database links:  
ASAP:
 ABE-0011993
CGSC:
 15448
ECHOBASE:
 EB1045
ECOLIHUB:
 uhpB
OU-MICROARRAY:
 b3668
STRING:
 511145.b3668
COLOMBOS: uhpB


Product      
Name: sensory histidine kinase UhpB
Synonym(s): UhpB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 56.306
Isoelectric point: 8.112
Motif(s):
 
Type Positions Sequence
12 -> 276 IACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLTQAVGLTHFPLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNTWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRL
36 -> 56 PDMAVLLFPFGLRLGLMLQCP
140 -> 160 ALLLTLTGGLTLAPICLVFWH
80 -> 100 LTHFPLLMIGSLLTLLPVALI
112 -> 132 LLLQGAALTAAALLQSLPWLW

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016787 - hydrolase activity
GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0004721 - phosphoprotein phosphatase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0000155 - phosphorelay sensor kinase activity
GO:0004673 - protein histidine kinase activity
GO:0046983 - protein dimerization activity
biological_process GO:0006470 - protein dephosphorylation
GO:0016310 - phosphorylation
GO:0000160 - phosphorelay signal transduction system
GO:0007165 - signal transduction
GO:0046777 - protein autophosphorylation
GO:0018106 - peptidyl-histidine phosphorylation
Note(s): Note(s): ...[more].
Reference(s): [1] Verhamme DT., et al., 2002
[2] Wright JS., et al., 2001
External database links:  
DIP:
 DIP-11083N
ECOCYC:
 UHPB-MONOMER
ECOLIWIKI:
 b3668
INTERPRO:
 IPR011712
INTERPRO:
 IPR036890
INTERPRO:
 IPR007895
INTERPRO:
 IPR005467
INTERPRO:
 IPR003594
MODBASE:
 P09835
PFAM:
 PF07730
PFAM:
 PF05231
PFAM:
 PF02518
PRIDE:
 P09835
PRODB:
 PRO_000024169
PROSITE:
 PS50109
REFSEQ:
 NP_418124
SMART:
 SM00387
SMR:
 P09835
UNIPROT:
 P09835


Operon      
Name: ivbL-ilvBN-uhpABC         
Operon arrangement:
Transcription unit        Promoter
uhpB
ivbL
ivbL-ilvBN
ivbL-ilvBN-uhpABC
uhpABC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4250 3850755 reverse nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Verhamme DT., Postma PW., Crielaard W., Hellingwerf KJ., 2002, Cooperativity in signal transfer through the Uhp system of Escherichia coli., J Bacteriol 184(15):4205-10

 [2] Wright JS., Kadner RJ., 2001, The phosphoryl transfer domain of UhpB interacts with the response regulator UhpA., J Bacteriol 183(10):3149-59

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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