RegulonDB RegulonDB 11.1: Gene Form
   

rsmH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ftsI rsmH mraZ ftsL ftsO murE LexA TSS_159 TSS_159 ftsLp2 ftsLp2 ftsLp1 ftsLp1 TSS_158 TSS_158 TSS_157 (cluster) TSS_157 (cluster) rsmHp1 rsmHp1

Gene      
Name: rsmH    Texpresso search in the literature
Synonym(s): ECK0083, EG11085, b0082, mraW, yabC
Genome position(nucleotides): 90094 --> 91035
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.2
External database links:  
ASAP:
 ABE-0000304
ECHOBASE:
 EB1077
ECOLIHUB:
 rsmH
OU-MICROARRAY:
 b0082
STRING:
 511145.b0082
COLOMBOS: rsmH


Product      
Name: 16S rRNA m4C1402 methyltransferase
Synonym(s): MraW, RsmH, YabC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 34.878
Isoelectric point: 6.389
Motif(s):
 
Type Positions Sequence Comment
5 -> 310 YKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAKTIDDPRFSIIHGPFSALGEYVAERDLIGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTYGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLNVLAPGGRLSIISFHSLEDRIVKRFMRENSRGPQVPAGLPMTEEQLKKLGGRQLRALGKLMPGEEEVAENPRARSSVLRIAER
35 -> 37 GGH UniProt: S-adenosyl-L-methionine binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.2 - RNA related --> 2.2.3 - RNA modification
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0008168 - methyltransferase activity
GO:0016740 - transferase activity
GO:0042803 - protein homodimerization activity
GO:0071424 - rRNA (cytosine-N4-)-methyltransferase activity
biological_process GO:0006364 - rRNA processing
GO:0032259 - methylation
GO:0070475 - rRNA base methylation
External database links:  
ALPHAFOLD:
 P60390
DIP:
 DIP-35840N
ECOCYC:
 EG11085-MONOMER
ECOLIWIKI:
 b0082
INTERPRO:
 IPR023397
INTERPRO:
 IPR029063
INTERPRO:
 IPR002903
MODBASE:
 P60390
PANTHER:
 PTHR11265
PDB:
 3TKA
PFAM:
 PF01795
PRIDE:
 P60390
PRODB:
 PRO_000023282
REFSEQ:
 NP_414624
SMR:
 P60390
SWISSMODEL:
 P60390
UNIPROT:
 P60390


Operon      
Name: mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC         
Operon arrangement:
Transcription unit        Promoter
mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsQ
ftsQAZ
ftsQAZ
ftsAZ
ftsZ
ftsZ
ftsZ
lpxC
lpxC


Transcriptional Regulation      
Display Regulation             
Repressed by: MraZ, PdhR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_157 (cluster) 90327 forward nd [RS-EPT-CBR] [1]
  promoter TSS_158 90367 forward nd [RS-EPT-CBR] [1]
  promoter TSS_159 92485 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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