RegulonDB RegulonDB 11.1: Gene Form
   

ygeA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

araE lysA lysR ygeA anti-anti-terminator anti-terminator terminator ygeAp5 ygeAp5 TSS_3140 TSS_3140 lysAp lysAp lysRp lysRp

Gene      
Name: ygeA    Texpresso search in the literature
Synonym(s): ECK2838, EG11157, b2840
Genome position(nucleotides): 2979943 <-- 2980635
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.94
External database links:  
ASAP:
 ABE-0009315
ECHOBASE:
 EB1146
ECOLIHUB:
 ygeA
OU-MICROARRAY:
 b2840
STRING:
 511145.b2840
COLOMBOS: ygeA


Product      
Name: amino acid racemase YgeA
Synonym(s): YgeA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 25.248
Isoelectric point: 4.851
Motif(s):
 
Type Positions Sequence Comment
7 -> 223 LGGMSWESTIPYYRLINEGIKQRLGGLHSAQVLLHSVDFHEIEECQRRGEWDKTGDILAEAALGLQRAGAEGIVLCTNTMHKVADAIESRCTLPFLHIADATGRAITGAGMTRVALLGTRYTMEQDFYRGRLTEQFSINCLIPEADERAKINQIIFEELCLGQFTEASRAYCAQVIARLAEQGAQGVIFGCTEIGLLVPEERSVLPVFDTAAIHAED
83 -> 85 TNT UniProt: Substrate binding; Sequence Annotation Type: region of interest.
198 -> 199 TE UniProt: Substrate binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016853 - isomerase activity
GO:0016855 - racemase and epimerase activity, acting on amino acids and derivatives
GO:0047661 - amino-acid racemase activity
GO:0036361 - racemase activity, acting on amino acids and derivatives
biological_process GO:0006807 - nitrogen compound metabolic process
External database links:  
ALPHAFOLD:
 P03813
DIP:
 DIP-12147N
ECOCYC:
 EG11157-MONOMER
ECOLIWIKI:
 b2840
INTERPRO:
 IPR018187
INTERPRO:
 IPR033134
INTERPRO:
 IPR015942
INTERPRO:
 IPR004380
INTERPRO:
 IPR001920
MODBASE:
 P03813
PANTHER:
 PTHR21198:SF7
PFAM:
 PF01177
PRIDE:
 P03813
PROSITE:
 PS00924
PROSITE:
 PS00923
REFSEQ:
 NP_417317
SMR:
 P03813
UNIPROT:
 P03813


Operon      
Name: araE-ygeA         
Operon arrangement:
Transcription unit        Promoter
araE
araE-ygeA
ygeA


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, AraC


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3140 2978995 forward nd [RS-EPT-CBR] [1]
  promoter ygeAp5 2980803 reverse nd [COMP-AINF] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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