RegulonDB RegulonDB 11.1: Gene Form
   

pdeL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pdeL yahB yahV Cra Cra pdeLp3 pdeLp3 pdeLp1 pdeLp1 pdeLp2 pdeLp2

Gene      
Name: pdeL    Texpresso search in the literature
Synonym(s): ECK0313, EG11236, b0315, yahA
Genome position(nucleotides): 332371 --> 333459
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 45.91
External database links:  
ASAP:
 ABE-0001086
ECHOBASE:
 EB1218
ECOLIHUB:
 yahA
OU-MICROARRAY:
 b0315
STRING:
 511145.b0315
COLOMBOS: pdeL


Product      
Name: DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL
Synonym(s): PdeL, YahA
Sequence: Get amino acid sequence Fasta Format
Regulator Family: LuxR/UhpA
Cellular location: inner membrane
Molecular weight: 40.725
Isoelectric point: 6.389
Motif(s):
 
Type Positions Sequence Comment
18 -> 83 HLSLPGSVSEKERLLLKLLMQGMSVTEISQYRNRSAKTISHQKKQLFEKLGIQSDITFWRDIFFQY UniProt: HTH luxR-type.
25 -> 72 VSEKERLLLKLLMQGMSVTEISQYRNRSAKTISHQKKQLFEKLGIQSD
42 -> 61 VTEISQYRNRSAKTISHQKK UniProt: H-T-H motif.
60 -> 60 K UniProt: Does not bind to the PdeL box..
106 -> 360 HIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMKA UniProt: EAL.

 
Classification:
Multifun Terms (GenProtEC)  
  3 - regulation
Gene Ontology Terms (GO)  
cellular_component GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0042803 - protein homodimerization activity
GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity
GO:0000976 - transcription cis-regulatory region binding
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:0045893 - positive regulation of transcription, DNA-templated
External database links:  
ALPHAFOLD:
 P21514
ECOCYC:
 EG11236-MONOMER
ECOLIWIKI:
 b0315
INTERPRO:
 IPR035919
INTERPRO:
 IPR036388
INTERPRO:
 IPR016032
INTERPRO:
 IPR001633
INTERPRO:
 IPR000792
MODBASE:
 P21514
PDB:
 4KIE
PDB:
 4LJ3
PDB:
 4LYK
PFAM:
 PF00563
PFAM:
 PF00196
PRIDE:
 P21514
PROSITE:
 PS50043
PROSITE:
 PS50883
REFSEQ:
 NP_414849
SMART:
 SM00052
SMART:
 SM00421
SMR:
 P21514
UNIPROT:
 P21514


Operon      
Name: pdeL         
Operon arrangement:
Transcription unit        Promoter
pdeL
pdeL
pdeL


Transcriptional Regulation      
Display Regulation             
Activated by: PdeL
Repressed by: Cra


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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