RegulonDB RegulonDB 10.9: Gene Form
   

tnaC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tnaA mnmE tnaC TorR CRP TorR terminator tnaCp tnaCp

Gene      
Name: tnaC    Texpresso search in the literature
Synonym(s): ECK3700, EG11276, b3707, tnaL
Genome position(nucleotides): 3888435 --> 3888509 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
34.67
External database links:  
ASAP:
ABE-0012128
ECHOBASE:
EB1254
ECOLIHUB:
tnaC
OU-MICROARRAY:
b3707
STRING:
511145.b3707
COLOMBOS: tnaC


Product      
Name: tnaAB operon leader peptide
Synonym(s): TnaC, TnaL, tryptophanase leader peptide, tryptophanase operon leader peptide
Sequence: Get amino acid sequence Fasta Format
Molecular weight: 2.894
Isoelectric point: 8.551
Motif(s):
 
Type Positions Sequence
1 -> 24 MNILHICVTSKWFNIDNKIVDHRP

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)  
biological_process GO:0031554 - regulation of DNA-templated transcription, termination
GO:0031556 - transcriptional attenuation by ribosome
GO:0090358 - positive regulation of tryptophan metabolic process
Note(s): Note(s): ...[more].
Evidence: [IMP] Inferred from mutant phenotype
Reference(s): [1] Chu HY., et al., 2017
[2] Gish K., et al., 1993
[3] Mihailovic MK., et al., 2018
[4] Seidelt B., et al., 2009
[5] Tanner DR., et al., 2009
External database links:  
ECOCYC:
EG11276-MONOMER
ECOLIWIKI:
b3707
INTERPRO:
IPR012620
PDB:
4UY8
PDB:
6I0Y
PDB:
5M6S
PFAM:
PF08053
PRIDE:
P0AD89
REFSEQ:
NP_418163
SMR:
P0AD89
UNIPROT:
P0AD89


Operon      
Name: tnaCAB         
Operon arrangement:
Transcription unit        Promoter
tnaC
tnaCAB


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, TorR


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Chu HY., Sprouffske K., Wagner A., 2017, The role of recombination in evolutionary adaptation of Escherichia coli to a novel nutrient., J Evol Biol 30(9):1692-1711

 [2] Gish K., Yanofsky C., 1993, Inhibition of expression of the tryptophanase operon in Escherichia coli by extrachromosomal copies of the tna leader region., J Bacteriol 175(11):3380-7

 [3] Mihailovic MK., Vazquez-Anderson J., Li Y., Fry V., Vimalathas P., Herrera D., Lease RA., Powell WB., Contreras LM., 2018, High-throughput in vivo mapping of RNA accessible interfaces to identify functional sRNA binding sites., Nat Commun 9(1):4084

 [4] Seidelt B., Innis CA., Wilson DN., Gartmann M., Armache JP., Villa E., Trabuco LG., Becker T., Mielke T., Schulten K., Steitz TA., Beckmann R., 2009, Structural insight into nascent polypeptide chain-mediated translational stalling., Science 326(5958):1412-5

 [5] Tanner DR., Cariello DA., Woolstenhulme CJ., Broadbent MA., Buskirk AR., 2009, Genetic identification of nascent peptides that induce ribosome stalling., J Biol Chem 284(50):34809-18


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