RegulonDB RegulonDB 10.10: Gene Form
   

gspO gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gspL gspO bfr gspM TSS_3834 TSS_3834

Gene      
Name: gspO    Texpresso search in the literature
Synonym(s): ECK3322, EG11359, b3335, hofD, hopD, hopO, yheC
Genome position(nucleotides): 3465543 --> 3466220 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.44
External database links:  
ASAP:
 ABE-0010901
ECHOBASE:
 EB1334
ECOLIHUB:
 gspO
OU-MICROARRAY:
 b3335
STRING:
 511145.b3335
COLOMBOS: gspO


Product      
Name: Type II secretion system prepilin peptidase
Synonym(s): GspO, HofD, HopD, HopO, YheC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 24.957
Isoelectric point: 7.819
Motif(s):
 
Type Positions Sequence
203 -> 223 IAFGPWLALGSMINLGYLAWI
175 -> 195 PMILLIASLGGIGYAIVSQLL
68 -> 88 ALAPFTPIVTGALFLYFCFVL
104 -> 124 LTLPLLWLGLVFNAQYGLIDL
3 -> 23 MLLPLFILVGFIADYFVNAIA

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0016740 - transferase activity
GO:0004190 - aspartic-type endopeptidase activity
biological_process GO:0006508 - proteolysis
GO:0006465 - signal peptide processing
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 EG11359-MONOMER
ECOLIWIKI:
 b3335
INTERPRO:
 IPR000045
INTERPRO:
 IPR014032
PFAM:
 PF01478
PRIDE:
 P25960
PRINTS:
 PR00864
PRODB:
 PRO_000022912
REFSEQ:
 NP_417794
UNIPROT:
 P25960


Operon      
Name: gspCDEFGHIJKLMO         
Operon arrangement:
Transcription unit        Promoter
gspCDEFGHIJKLMO
gspCDEFGHIJKLMO
gspCDEFGHIJKLMO


Transcriptional Regulation      
Display Regulation             
Activated by: SlyA
Repressed by: H-NS, Fur


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3834 3464173 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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