RegulonDB

Gene
Name:	cynR
Synonym(s):	ECK0335, EG11421, b0338
Genome position(nucleotides):	357791 <-- 358690
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	55.0
External database links:

ASAP:	ABE-0001165
CGSC:	31255
ECHOBASE:	EB1391
ECOLIHUB:	cynR
OU-MICROARRAY:	b0338
STRING:	511145.b0338
COLOMBOS:	cynR

Shine dalgarno
Sequence:	ggatttacttATAGGTtgcgAAT

Product

Name:

DNA-binding transcriptional dual regulator CynR

Synonym(s):

CynR

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

LysR

Cellular location:

cytosol

Molecular weight:

32.961

Isoelectric point:

6.854

Motif(s):

Type	Positions	Sequence	Comment
	1 -> 58	MLSRHINYFLAVAEHGSFTRAASALHVSQPALSQQIRQLEESLGVPLFDRSGRTIRLT	UniProt: HTH lysR-type.
	4 -> 62	RHINYFLAVAEHGSFTRAASALHVSQPALSQQIRQLEESLGVPLFDRSGRTIRLTDAGE
	18 -> 37	FTRAASALHVSQPALSQQIR	UniProt: H-T-H motif.
	88 -> 290	LTRGSLRIAVTPTFTSYFIGPLMADFYARYPSITLQLQEMSQEKIEDMLCRDELDVGIAFAPVHSPELEAIPLLTESLALVVAQHHPLAVHEQVALSRLHDEKLVLLSAEFATREQIDHYCEKAGLHPQVVIEANSISAVLELIRRTSLSTLLPAAIATQHDGLKAISLAPPLLERTAVLLRRKNSWQTAAAKAFLHMALDKC

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.1 - unassigned reversible reactions
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
		5 - cell processes --> 5.6 - protection --> 5.6.2 - detoxification
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032993 - protein-DNA complex
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity
	biological_process	GO:0006355 - regulation of transcription, DNA-templated

Reference(s):

[1] Lamblin AF., et al., 1994
[2] Lamblin AF., et al., 1993
[3] Sung YC., et al., 1992

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PFAM:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Repressed by:	CynR

Reference(s)
[1] Lamblin AF., Fuchs JA., 1994, Functional analysis of the Escherichia coli K-12 cyn operon transcriptional regulation., J Bacteriol 176(21):6613-22
[2] Lamblin AF., Fuchs JA., 1993, Expression and purification of the cynR regulatory gene product: CynR is a DNA-binding protein., J Bacteriol 175(24):7990-9
[3] Sung YC., Fuchs JA., 1992, The Escherichia coli K-12 cyn operon is positively regulated by a member of the lysR family., J Bacteriol 174(11):3645-50