RegulonDB RegulonDB 11.1: Gene Form
   

fabI gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yciW fabI ycjD FadR CysB terminator terminator terminator fabIp fabIp fabIp1 fabIp1 yciWp4 yciWp4 yciWp yciWp rnbp1 rnbp1

Gene      
Name: fabI    Texpresso search in the literature
Synonym(s): ECK1283, EG11528, b1288, envM, gts, qmeA
Genome position(nucleotides): 1350251 <-- 1351039
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.23
External database links:  
ASAP:
 ABE-0004327
CGSC:
 812
ECHOBASE:
 EB1490
ECOLIHUB:
 fabI
OU-MICROARRAY:
 b1288
STRING:
 511145.b1288
COLOMBOS: fabI


Product      
Name: enoyl-[acyl-carrier-protein] reductase
Synonym(s): EnvM, FabI, Gts, QmeA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,membrane
Molecular weight: 27.864
Isoelectric point: 5.664
Motif(s):
 
Type Positions Sequence Comment
2 -> 262 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK UniProt: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI.
13 -> 252 GVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFS
19 -> 20 SI UniProt: NAD.
64 -> 65 DV UniProt: NAD.
93 -> 93 G UniProt: Diazaborine resistance..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.4 - fatty acids and phosphatidic acid
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0032991 - protein-containing complex
GO:1902494 - catalytic complex
molecular_function GO:0005515 - protein binding
GO:0016491 - oxidoreductase activity
GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016631 - enoyl-[acyl-carrier-protein] reductase activity
GO:0042802 - identical protein binding
GO:0070404 - NADH binding
biological_process GO:0006629 - lipid metabolic process
GO:0006631 - fatty acid metabolic process
GO:0008610 - lipid biosynthetic process
GO:0009102 - biotin biosynthetic process
GO:0046677 - response to antibiotic
GO:0006633 - fatty acid biosynthetic process
GO:0051289 - protein homotetramerization
GO:0030497 - fatty acid elongation
External database links:  
ALPHAFOLD:
 P0AEK4
DIP:
 DIP-31867N
ECOCYC:
 ENOYL-ACP-REDUCT-NADH-MONOMER
ECOLIWIKI:
 b1288
INTERPRO:
 IPR002347
INTERPRO:
 IPR014358
INTERPRO:
 IPR036291
PANTHER:
 PTHR43159:SF2
PDB:
 1MFP
PDB:
 1QG6
PDB:
 1QSG
PDB:
 2FHS
PDB:
 3PJD
PDB:
 3PJE
PDB:
 3PJF
PDB:
 4JQC
PDB:
 4JX8
PDB:
 5CFZ
PDB:
 5CG1
PDB:
 5CG2
PDB:
 1LXC
PDB:
 1LX6
PDB:
 1I30
PDB:
 1I2Z
PDB:
 1DFI
PDB:
 1DFH
PDB:
 1DFG
PDB:
 1C14
PDB:
 1D8A
PFAM:
 PF13561
PRIDE:
 P0AEK4
PRINTS:
 PR00081
PRODB:
 PRO_000022565
REFSEQ:
 NP_415804
SMR:
 P0AEK4
SWISSMODEL:
 P0AEK4
UNIPROT:
 P0AEK4


Operon      
Name: fabI         
Operon arrangement:
Transcription unit        Promoter
fabI
fabI


Transcriptional Regulation      
Display Regulation             
Activated by: FadR


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yciWp4 1350236 reverse nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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