RegulonDB RegulonDB 11.1: Gene Form
   

talB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yaaJ talB mog TSS_25 (cluster) TSS_25 (cluster) TSS_24 TSS_24 TSS_23 TSS_23 TSS_22 TSS_22 TSS_21 (cluster) TSS_21 (cluster) TSS_20 TSS_20 TSS_19 TSS_19 talBp talBp yaaJp4 yaaJp4 yaaAp5 yaaAp5 yaaAp3 yaaAp3

Gene      
Name: talB    Texpresso search in the literature
Synonym(s): ECK0008, EG11556, b0008, yaaK
Genome position(nucleotides): 8238 --> 9191
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.99
External database links:  
ASAP:
 ABE-0000027
CGSC:
 36818
ECHOBASE:
 EB1517
ECOLIHUB:
 talB
MIM:
 606003
OU-MICROARRAY:
 b0008
STRING:
 511145.b0008
COLOMBOS: talB


Product      
Name: transaldolase B
Synonym(s): TalB, YaaK
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,membrane
Molecular weight: 35.219
Isoelectric point: 4.838
Motif(s):
 
Type Positions Sequence Comment
2 -> 317 TDKLTSLRQYTTVVADTGDIAAMKLYQPQDATTNPSLILNAAQIPEYRKLIDDAVAWAKQQSNDRAQQIVDATDKLAVNIGLEILKLVPGRISTEVDARLSYDTEASIAKAKRLIKLYNDAGISNDRILIKLASTWQGIRAAEQLEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRILDWYKANTDKKEYAPAEDPGVVSVSEIYQYYKEHGYETVVMGASFRNIGEILELAGCDRLTIAPALLKELAESEGAIERKLSYTGEVKARPARITESEFLWQHNQDPMAVDKLAEGIRKFAIDQEKLEKMIGDLL UniProt: Transaldolase B.
14 -> 313 VVADTGDIAAMKLYQPQDATTNPSLILNAAQIPEYRKLIDDAVAWAKQQSNDRAQQIVDATDKLAVNIGLEILKLVPGRISTEVDARLSYDTEASIAKAKRLIKLYNDAGISNDRILIKLASTWQGIRAAEQLEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRILDWYKANTDKKEYAPAEDPGVVSVSEIYQYYKEHGYETVVMGASFRNIGEILELAGCDRLTIAPALLKELAESEGAIERKLSYTGEVKARPARITESEFLWQHNQDPMAVDKLAEGIRKFAIDQEKLEKMI

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.3 - non-oxidative branch, pentose pathway
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0004801 - transaldolase activity
GO:0016744 - transketolase or transaldolase activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0009052 - pentose-phosphate shunt, non-oxidative branch
GO:0006098 - pentose-phosphate shunt
Note(s): Note(s): ...[more].
Reference(s): [1] Rahman M., et al., 2008
[2] Rale M., et al., 2011
External database links:  
ALPHAFOLD:
 P0A870
DIP:
 DIP-31850N
ECOCYC:
 TRANSALDOLB-MONOMER
ECOLIWIKI:
 b0008
INTERPRO:
 IPR001585
INTERPRO:
 IPR013785
INTERPRO:
 IPR004730
INTERPRO:
 IPR018225
MODBASE:
 P0A870
PANTHER:
 PTHR10683
PANTHER:
 PTHR10683:SF18
PDB:
 4S2C
PDB:
 4S2B
PDB:
 4RZ6
PDB:
 4RZ5
PDB:
 3KOF
PDB:
 1UCW
PDB:
 1ONR
PDB:
 1I2R
PDB:
 1I2Q
PDB:
 1I2P
PDB:
 1I2N
PDB:
 1I2O
PFAM:
 PF00923
PRIDE:
 P0A870
PROSITE:
 PS01054
PROSITE:
 PS00958
REFSEQ:
 NP_414549
SMR:
 P0A870
UNIPROT:
 P0A870


Operon      
Name: talB         
Operon arrangement:
Transcription unit        Promoter
talB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yaaAp3 6587 reverse nd [COMP-AINF] [3]
  promoter yaaAp5 6615 reverse nd [COMP-AINF] [3]
  promoter yaaJp4 8017 reverse nd [COMP-AINF] [3]
  promoter TSS_19 8198 forward nd [RS-EPT-CBR] [4]
  promoter TSS_20 8211 forward nd [RS-EPT-CBR] [4]
  promoter TSS_21 (cluster) 8229 forward nd [RS-EPT-CBR] [4]
  promoter TSS_22 8232 forward nd [RS-EPT-CBR] [4]
  promoter TSS_23 8352 forward nd [RS-EPT-CBR] [4]
  promoter TSS_24 8638 forward nd [RS-EPT-CBR] [4]
  promoter TSS_25 (cluster) 9277 forward nd [RS-EPT-CBR] [4]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Rahman M., Hasan MR., Shimizu K., 2008, Growth phase-dependent changes in the expression of global regulatory genes and associated metabolic pathways in Escherichia coli., Biotechnol Lett 30(5):853-60

 [2] Rale M., Schneider S., Sprenger GA., Samland AK., Fessner WD., 2011, Broadening deoxysugar glycodiversity: natural and engineered transaldolases unlock a complementary substrate space., Chemistry 17(9):2623-32

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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