RegulonDB RegulonDB 11.1: Gene Form
   

yedK gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yedK yedL yedF yedE

Gene      
Name: yedK    Texpresso search in the literature
Synonym(s): ECK1930, EG11662, b1931, yedG
Genome position(nucleotides): 2009821 --> 2010489
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.87
External database links:  
ASAP:
 ABE-0006428
ECHOBASE:
 EB3063
ECOLIHUB:
 yedK
OU-MICROARRAY:
 b1931
STRING:
 511145.b1931
COLOMBOS: yedK


Product      
Name: genome maintenance protein
Synonym(s): YedG, YedK, abasic site processing protein
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 24.979
Isoelectric point: 4.991
Motif(s):
 
Type Positions Sequence Comment
1 -> 211 MCGRFAQSQTREDYLALLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVETAATSRMFKPLWQHGRAICFADGWFEWKKEGDKKQPFFIYRADGQPIFMAAIGSTPFERGDEAEGFLIVTAAADQGLVDIHDRRPLVLSPEAAREWMRQEISGKEASEIAASGCVPANQFSWHPVSRAVGNV
2 -> 2 C UniProt: Abolished formation of the DNA-protein cross-link. Reduced binding to single-stranded DNA..
4 -> 4 R UniProt: Reduced binding to single-stranded DNA..
40 -> 40 P UniProt: Reduced binding to single-stranded DNA..
67 -> 67 W UniProt: Abolished binding to single-stranded DNA..

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.6 - protection
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0003697 - single-stranded DNA binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
biological_process GO:0018142 - protein-DNA covalent cross-linking
GO:0006508 - proteolysis
GO:0006974 - cellular response to DNA damage stimulus
GO:0009432 - SOS response
Note(s): Note(s): ...[more].
Reference(s): [1] Aravind L., et al., 2013
[2] Kweon SM., et al., 2017
[3] Nowotny M. 2019
External database links:  
ALPHAFOLD:
 P76318
ECOCYC:
 EG11662-MONOMER
ECOLIWIKI:
 b1931
INTERPRO:
 IPR003738
INTERPRO:
 IPR036590
PANTHER:
 PTHR13604
PDB:
 6KBX
PDB:
 6NUA
PDB:
 6NUH
PDB:
 6KBU
PDB:
 6KCQ
PDB:
 6KIJ
PDB:
 6KBZ
PDB:
 2ICU
PDB:
 6KBS
PFAM:
 PF02586
PRIDE:
 P76318
REFSEQ:
 YP_025310
SMR:
 P76318
SWISSMODEL:
 P76318
UNIPROT:
 P76318


Operon      
Name: yedK         
Operon arrangement:
Transcription unit        Promoter
yedK


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Aravind L., Anand S., Iyer LM., 2013, Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems., Biol Direct 8:20

 [2] Kweon SM., Zhu B., Chen Y., Aravind L., Xu SY., Feldman DE., 2017, Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease., Cell Rep 21(2):482-494

 [3] Nowotny M., 2019, Crosslink and shield: protecting abasic sites from error-prone repair., Nat Struct Mol Biol 26(7):530-532

RegulonDB