RegulonDB RegulonDB 11.1: Gene Form
   

aas gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aas lplT tas omrA omrAp omrAp TSS_3137 TSS_3137 TSS_3136 TSS_3136 lplTp3 lplTp3 TSS_3135 TSS_3135

Gene      
Name: aas    Texpresso search in the literature
Synonym(s): ECK2832, EG11679, b2836
Genome position(nucleotides): 2973855 <-- 2976014
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.64
External database links:  
ASAP:
 ABE-0009302
CGSC:
 29780
ECHOBASE:
 EB1630
ECOLIHUB:
 aas
OU-MICROARRAY:
 b2836
STRING:
 511145.b2836
COLOMBOS: aas


Product      
Name: fused 2-acylglycerophospho-ethanolamine acyltransferase/acyl-acyl carrier protein synthetase
Synonym(s): Aas, acyltransferase
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 80.7
Isoelectric point: 9.706
Motif(s):
 
Type Positions Sequence Comment
15 -> 16 RV UniProt: In Ref. 1; AAA17550..
36 -> 36 H UniProt: Loss of 2-acyl-GPE acyltransferase activity; retains acyl-ACP synthetase activity..
202 -> 202 P UniProt: In Ref. 1; AAA17550..
233 -> 619 SYRKLLTKTLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRMPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKI
258 -> 277 IGLMLPNAGISAAVIFGAIA UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.4 - fatty acids and phosphatidic acid
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0016874 - ligase activity
GO:0016746 - acyltransferase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0008779 - acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
GO:0008922 - long-chain fatty acid [acyl-carrier-protein] ligase activity
biological_process GO:0008152 - metabolic process
GO:0006631 - fatty acid metabolic process
GO:0008654 - phospholipid biosynthetic process
GO:0001676 - long-chain fatty acid metabolic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P31119
DIP:
 DIP-9025N
ECOCYC:
 AAS-MONOMER
ECOLIWIKI:
 b2836
INTERPRO:
 IPR002123
INTERPRO:
 IPR000873
INTERPRO:
 IPR023775
INTERPRO:
 IPR042099
INTERPRO:
 IPR020845
MODBASE:
 P31119
PFAM:
 PF00501
PFAM:
 PF01553
PRIDE:
 P31119
PRODB:
 PRO_000022025
PROSITE:
 PS00455
REFSEQ:
 NP_417313
SMART:
 SM00563
SMR:
 P31119
UNIPROT:
 P31119


Operon      
Name: aas-lplT         
Operon arrangement:
Transcription unit        Promoter
aas-lplT


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3135 2971604 forward nd [RS-EPT-CBR] [1]
  promoter lplTp3 2973939 reverse nd [COMP-AINF] [2]
  promoter TSS_3136 2975992 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3137 2976050 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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