RegulonDB RegulonDB 11.1: Gene Form
   

gpmA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aroG galM gpmA galK Fur Fur TSS_931 TSS_931 gpmAp3 gpmAp3 gpmAp2 gpmAp2 gpmAp4 gpmAp4 gpmAp gpmAp TSS_928 TSS_928 TSS_927 TSS_927 TSS_926 TSS_926 TSS_925 (cluster) TSS_925 (cluster) TSS_924 (cluster) TSS_924 (cluster) TSS_923 TSS_923

Gene      
Name: gpmA    Texpresso search in the literature
Synonym(s): ECK0744, EG11699, b0755, gpm
Genome position(nucleotides): 786843 <-- 787595
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.0
External database links:  
ASAP:
 ABE-0002563
CGSC:
 35790
ECHOBASE:
 EB1650
ECOLIHUB:
 gpmA
MIM:
 261670
OU-MICROARRAY:
 b0755
STRING:
 511145.b0755
COLOMBOS: gpmA


Product      
Name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Synonym(s): Gpm, GpmA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 28.556
Isoelectric point: 6.071
Motif(s):
 
Type Positions Sequence Comment
2 -> 250 AVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNETILPRMKSGERVIIAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKPLKRYYLGNADEIAAKAAAVANQGKAK UniProt: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.
6 -> 224 LVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNETILPRMKSGERVIIAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKP
10 -> 17 RHGESQWN UniProt: Substrate binding; Sequence Annotation Type: region of interest.
23 -> 24 TG UniProt: Substrate binding; Sequence Annotation Type: region of interest.
89 -> 92 ERHY UniProt: Substrate binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.1 - glycolysis
  1 - metabolism --> 1.7 - central intermediary metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016853 - isomerase activity
GO:0016868 - intramolecular transferase activity, phosphotransferases
GO:0005524 - ATP binding
GO:0004619 - phosphoglycerate mutase activity
GO:0042803 - protein homodimerization activity
GO:0046538 - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0097216 - guanosine tetraphosphate binding
biological_process GO:0061621 - canonical glycolysis
GO:0006094 - gluconeogenesis
GO:0006096 - glycolytic process
External database links:  
ALPHAFOLD:
 P62707
DIP:
 DIP-35899N
ECOCYC:
 GPMA-MONOMER
ECOLIWIKI:
 b0755
INTERPRO:
 IPR013078
INTERPRO:
 IPR001345
INTERPRO:
 IPR029033
INTERPRO:
 IPR005952
PANTHER:
 PTHR11931
PDB:
 1E58
PDB:
 1E59
PFAM:
 PF00300
PRIDE:
 P62707
PRODB:
 PRO_000022830
PROSITE:
 PS00175
REFSEQ:
 NP_415276
SMART:
 SM00855
SMR:
 P62707
UNIPROT:
 P62707


Operon      
Name: gpmA         
Operon arrangement:
Transcription unit        Promoter
gpmA
gpmA
gpmA
gpmA


Transcriptional Regulation      
Display Regulation             
Repressed by: Fur


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_923 785768 forward nd [RS-EPT-CBR] [1]
  promoter TSS_924 (cluster) 785886 forward nd [RS-EPT-CBR] [1]
  promoter TSS_925 (cluster) 785890 forward nd [RS-EPT-CBR] [1]
  promoter TSS_926 785897 forward nd [RS-EPT-CBR] [1]
  promoter TSS_927 787626 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_928 787629 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_931 787682 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB